Fueling the fire in acute kidney injury: Endothelial cells collect their Toll

Research output: Contribution to journalComment/debate

3 Scopus citations


Chen et al. demonstrate endothelial expression of Toll-like receptor 4 (TLR4) in the outer medulla of the kidney early in the course of ischemic acute kidney injury. Furthermore, they provide data that support the hypothesis that activation of endothelial TLR4 in the early extension phase of AKI by damage-associated molecular pattern molecules released from injured tubules results in endothelial activation. This activation can serve to amplify inflammation and tubular damage.

Original languageEnglish (US)
Pages (from-to)267-269
Number of pages3
JournalKidney international
Issue number3
StatePublished - Feb 2011


ASJC Scopus subject areas

  • Nephrology

Cite this