Fully automated synthesis and initial PET evaluation of [11C]PBR28

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35 Scopus citations

Abstract

Fully automated synthesis and initial PET evaluation of a TSPO radioligand, [11C]PBR28 (N-(2-[11C]methoxybenzyl)-N-(4-phenoxypyridin-3-yl)acetamide), are reported. These results facilitate the potential preclinical and clinical PET studies of [11C]PBR28 in animals and humans.

Original languageEnglish (US)
Pages (from-to)5636-5639
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number19
DOIs
StatePublished - Oct 1 2009

Keywords

  • [C]PBR28
  • Brain imaging
  • Positron emission tomography (PET)
  • Radiosynthesis
  • Translocator protein (TSPO)
  • Traumatic brain injury (TBI)

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

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