Fully automated synthesis of PET TSPO radioligands [ 11C]DAA1106 and [ 18F]FEDAA1106

Min Wang, Mingzhang Gao, Qi Huang Zheng

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

[ 11C]DAA1106 was prepared by O-[ 11C]methylation of DAA1123 with [ 11C]CH 3OTf and NaH in CH 3CN at 80°C and isolated by HPLC combined with SPE purification in 60-70% decay corrected radiochemical yield. [ 18F]FEDAA1106 was synthesized by the nucleophilic substitution of tosyloxy-FEDAA1106 in DMSO with K[ 18F]F/Kryptofix 2.2.2 at 140°C and isolated by HPLC combined with SPE purification in 30-60% decay corrected radiochemical yield. The specific activity for [ 11C]DAA1106 and [ 18F]FEDAA1106 was 370-740GBq/μmol and 37-222GBq/μmol at EOB, respectively.

Original languageEnglish (US)
Pages (from-to)965-973
Number of pages9
JournalApplied Radiation and Isotopes
Volume70
Issue number6
DOIs
StatePublished - Jun 1 2012

Keywords

  • [ C]DAA1106
  • [ F]FEDAA1106
  • Automation
  • Positron emission tomography (PET)
  • Radiosynthesis
  • Translocator protein 18kDa (TSPO)

ASJC Scopus subject areas

  • Radiation

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