[ 11C]DAA1106 was prepared by O-[ 11C]methylation of DAA1123 with [ 11C]CH 3OTf and NaH in CH 3CN at 80°C and isolated by HPLC combined with SPE purification in 60-70% decay corrected radiochemical yield. [ 18F]FEDAA1106 was synthesized by the nucleophilic substitution of tosyloxy-FEDAA1106 in DMSO with K[ 18F]F/Kryptofix 2.2.2 at 140°C and isolated by HPLC combined with SPE purification in 30-60% decay corrected radiochemical yield. The specific activity for [ 11C]DAA1106 and [ 18F]FEDAA1106 was 370-740GBq/μmol and 37-222GBq/μmol at EOB, respectively.
- [ C]DAA1106
- [ F]FEDAA1106
- Positron emission tomography (PET)
- Translocator protein 18kDa (TSPO)
ASJC Scopus subject areas