Fulminant Liver Failure Induced by Adenovirus after Bone Marrow Transplantation

David T. Purtilo, Roberta White, Alexandria Filipovich, John Kersey, Leo Zelkowitz, Anthony F. Shields, Robert C. Hackman, Joel D. Meyers, Kenneth Fife, Lawrence Corey

Research output: Contribution to journalLetter

27 Citations (Scopus)

Abstract

To the Editor: In their report on adenovirus infections in patients undergoing bone marrow transplantation, Shields et al. (Feb. 28 issue)1 conclude that the most likely source of infection was endogenous viral reactivation. Alternatively, this agent may be nosocomially derived, as illustrated below. A 19-year-old man with the X-linked lymphoproliferative syndrome had a reactivation of Epstein–Barr virus seven years after the primary infection. In sequence, he had anemia with erythroblastopenia; signs, symptoms, and laboratory manifestations of acute infectious mononucleosis; and acquired agammaglobulinemia.2 Recurrent bouts of opportunistic infections and persistent erythroblastopenia and agammaglobulinemia prompted grafting of HLA-matched bone marrow from his.

Original languageEnglish (US)
Pages (from-to)1707-1708
Number of pages2
JournalNew England Journal of Medicine
Volume312
Issue number26
DOIs
StatePublished - Jun 27 1985

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Acute Liver Failure
Bone Marrow Transplantation
Adenoviridae
Adenoviridae Infections
Agammaglobulinemia
Infectious Mononucleosis
Lymphoproliferative Disorders
Opportunistic Infections
Infection
Signs and Symptoms
Anemia
Bone Marrow
Viruses

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Purtilo, D. T., White, R., Filipovich, A., Kersey, J., Zelkowitz, L., Shields, A. F., ... Corey, L. (1985). Fulminant Liver Failure Induced by Adenovirus after Bone Marrow Transplantation. New England Journal of Medicine, 312(26), 1707-1708. https://doi.org/10.1056/NEJM198506273122614

Fulminant Liver Failure Induced by Adenovirus after Bone Marrow Transplantation. / Purtilo, David T.; White, Roberta; Filipovich, Alexandria; Kersey, John; Zelkowitz, Leo; Shields, Anthony F.; Hackman, Robert C.; Meyers, Joel D.; Fife, Kenneth; Corey, Lawrence.

In: New England Journal of Medicine, Vol. 312, No. 26, 27.06.1985, p. 1707-1708.

Research output: Contribution to journalLetter

Purtilo, DT, White, R, Filipovich, A, Kersey, J, Zelkowitz, L, Shields, AF, Hackman, RC, Meyers, JD, Fife, K & Corey, L 1985, 'Fulminant Liver Failure Induced by Adenovirus after Bone Marrow Transplantation', New England Journal of Medicine, vol. 312, no. 26, pp. 1707-1708. https://doi.org/10.1056/NEJM198506273122614
Purtilo DT, White R, Filipovich A, Kersey J, Zelkowitz L, Shields AF et al. Fulminant Liver Failure Induced by Adenovirus after Bone Marrow Transplantation. New England Journal of Medicine. 1985 Jun 27;312(26):1707-1708. https://doi.org/10.1056/NEJM198506273122614
Purtilo, David T. ; White, Roberta ; Filipovich, Alexandria ; Kersey, John ; Zelkowitz, Leo ; Shields, Anthony F. ; Hackman, Robert C. ; Meyers, Joel D. ; Fife, Kenneth ; Corey, Lawrence. / Fulminant Liver Failure Induced by Adenovirus after Bone Marrow Transplantation. In: New England Journal of Medicine. 1985 ; Vol. 312, No. 26. pp. 1707-1708.
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