Fulminant Liver Failure Induced by Adenovirus after Bone Marrow Transplantation

David T. Purtilo, Roberta White, Alexandria Filipovich, John Kersey, Leo Zelkowitz, Anthony F. Shields, Robert C. Hackman, Joel D. Meyers, Kenneth H. Fife, Lawrence Corey

Research output: Contribution to journalLetter

27 Scopus citations


To the Editor: In their report on adenovirus infections in patients undergoing bone marrow transplantation, Shields et al. (Feb. 28 issue)1 conclude that the most likely source of infection was endogenous viral reactivation. Alternatively, this agent may be nosocomially derived, as illustrated below. A 19-year-old man with the X-linked lymphoproliferative syndrome had a reactivation of Epstein–Barr virus seven years after the primary infection. In sequence, he had anemia with erythroblastopenia; signs, symptoms, and laboratory manifestations of acute infectious mononucleosis; and acquired agammaglobulinemia.2 Recurrent bouts of opportunistic infections and persistent erythroblastopenia and agammaglobulinemia prompted grafting of HLA-matched bone marrow from his.

Original languageEnglish (US)
Pages (from-to)1707-1708
Number of pages2
JournalNew England Journal of Medicine
Issue number26
StatePublished - Jun 27 1985

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Fulminant Liver Failure Induced by Adenovirus after Bone Marrow Transplantation'. Together they form a unique fingerprint.

  • Cite this

    Purtilo, D. T., White, R., Filipovich, A., Kersey, J., Zelkowitz, L., Shields, A. F., Hackman, R. C., Meyers, J. D., Fife, K. H., & Corey, L. (1985). Fulminant Liver Failure Induced by Adenovirus after Bone Marrow Transplantation. New England Journal of Medicine, 312(26), 1707-1708. https://doi.org/10.1056/NEJM198506273122614