Function of anti-Streptococcus mutans antibodies: Anti-ribosomal antibodies inhibit acid production, growth, and glucose phosphotransferase activity

R. L. Gregory, S. M. Michalek, I. L. Shechmeister, J. R. McGhee

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Antibodies induced in sera and saliva of rats and rabbits immunized with ribosomal preparations from Streptococcus mutans 6715 inhibited transport of glucose by the phosphotransferase system by >60%, acid production from sucrose by >95%, and growth of the homologous S. mutans by >59%. Inhibition of growth and acid production by immune sera and saliva were abrogated by prior adsorption with S. mutans 6715 whole cells, glucosyltransferase, lipoteichoic acid, or α1-6 or α1-3 dextran. These results indicate that antibodies induced to an S. mutans ribosomal preparation react with cell surface determinants and suggest that the antibodies inhibit sucrose-induced acid formation and growth of virulent S. mutans by neutralizing the glucose-phosphotransferase system.

Original languageEnglish (US)
Pages (from-to)286-289
Number of pages4
JournalInfection and immunity
Volume45
Issue number1
StatePublished - Jan 1 1984

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ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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