Function of anti-Streptococcus mutans antibodies: Anti-ribosomal antibodies inhibit acid production, growth, and glucose phosphotransferase activity

Richard Gregory, S. M. Michalek, I. L. Shechmeister, J. R. McGhee

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Antibodies induced in sera and saliva of rats and rabbits immunized with ribosomal preparations from Streptococcus mutans 6715 inhibited transport of glucose by the phosphotransferase system by >60%, acid production from sucrose by >95%, and growth of the homologous S. mutans by >59%. Inhibition of growth and acid production by immune sera and saliva were abrogated by prior adsorption with S. mutans 6715 whole cells, glucosyltransferase, lipoteichoic acid, or α1-6 or α1-3 dextran. These results indicate that antibodies induced to an S. mutans ribosomal preparation react with cell surface determinants and suggest that the antibodies inhibit sucrose-induced acid formation and growth of virulent S. mutans by neutralizing the glucose-phosphotransferase system.

Original languageEnglish (US)
Pages (from-to)286-289
Number of pages4
JournalInfection and Immunity
Volume45
Issue number1
StatePublished - 1984
Externally publishedYes

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Streptococcus mutans
Anti-Idiotypic Antibodies
Phosphotransferases
Glucose
Acids
Antibodies
Growth
Saliva
Sucrose
Glucosyltransferases
Adsorption
Immune Sera
Rabbits
Serum

ASJC Scopus subject areas

  • Immunology

Cite this

Function of anti-Streptococcus mutans antibodies : Anti-ribosomal antibodies inhibit acid production, growth, and glucose phosphotransferase activity. / Gregory, Richard; Michalek, S. M.; Shechmeister, I. L.; McGhee, J. R.

In: Infection and Immunity, Vol. 45, No. 1, 1984, p. 286-289.

Research output: Contribution to journalArticle

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