Function of anti‐Strepfococcus mutans antibodies: inhibition of virulence factors and enzyme neutralization

Richard L. Gregory, Janice C. Kindle, Laura C. Hobbs, Steven J. Filler, Hans S. Malmstrom

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

The levels of parotid salivary IgA and serum IgG antibodies from dental caries‐resistant (CR) and caries‐susceptible (CS) individuals to Streptococcus mutans antigens were determined. In general, the levels of salivary IgA and serum IgG antibodies to S. mutans antigens were significantly higher in CR subjects than in CS individuals. There were significantly higher levels of IgA2, but not IgAl, salivary antibodies to S. mutans whole cells in CR subjects than in CS individuals. These results led us to investigate the functional effects parotid saliva and sera containing these antibodies had on several factors associated with S. mutans virulence. Parotid saliva and sera from CR subjects significantly inhibited S. mutans growth, adherence, acid production, glucosyltransferase and glucose‐phospho‐transferase activities to a greater extent than saliva and sera from CS individuals. The data suggest that neutralization of S. mutans enzymes and inhibition of S. wutans virulence factors by saliva and serum may be responsible for the lower numbers of carious lesions in CR subjects.

Original languageEnglish (US)
Pages (from-to)181-188
Number of pages8
JournalOral Microbiology and Immunology
Volume5
Issue number4
DOIs
StatePublished - Aug 1990

Keywords

  • Streptococcus mutans
  • caries
  • im‐munoglobulins A and G
  • neutralizing antibody

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Dentistry(all)
  • Microbiology (medical)

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