Function of mitochondrial Stat3 in cellular respiration

Joanna Wegrzyn, Ramesh Potla, Yong Joon Chwae, Naresh B V Sepuri, Qifang Zhang, Thomas Koeck, Marta Derecka, Karol Szczepanek, Magdalena Szelag, Agnieszka Gornicka, Akira Moh, Shadi Moghaddas, Qun Chen, Santha Bobbili, Joanna Cichy, Jozef Dulak, Darren P. Baker, Alan Wolfman, Dennis Stuehr, Medhat O. HassanXin Yuan Fu, Narayan Avadhani, Jennifer I. Drake, Paul Fawcett, Edward J. Lesnefsky, Andrew C. Larner

Research output: Contribution to journalArticle

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Abstract

Cytokines such as interleukin-6 induce tyrosine and serine phosphorylation of Stat3 that results in activation of Stat3-responsive genes. We provide evidence that Stat3 is present in the mitochondria of cultured cells and primary tissues, including the liver and heart. In Stat3-/- cells, the activities of complexes I and II of the electron transport chain (ETC) were significantly decreased. We identified Stat3 mutants that selectively restored the protein's function as a transcription factor or its functions within the ETC. In mice that do not express Stat3 in the heart, there were also selective defects in the activities of complexes I and II of the ETC. These data indicate that Stat3 is required for optimal function of the ETC, which may allow it to orchestrate responses to cellular homeostasis.

Original languageEnglish
Pages (from-to)793-797
Number of pages5
JournalScience
Volume323
Issue number5915
DOIs
StatePublished - Feb 6 2009

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Electron Transport Complex II
Cell Respiration
Electron Transport Complex I
Electron Transport
Serine
Tyrosine
Cultured Cells
Interleukin-6
Mitochondria
Homeostasis
Transcription Factors
Phosphorylation
Cytokines
Liver
Genes
Proteins

ASJC Scopus subject areas

  • General

Cite this

Wegrzyn, J., Potla, R., Chwae, Y. J., Sepuri, N. B. V., Zhang, Q., Koeck, T., ... Larner, A. C. (2009). Function of mitochondrial Stat3 in cellular respiration. Science, 323(5915), 793-797. https://doi.org/10.1126/science.1164551

Function of mitochondrial Stat3 in cellular respiration. / Wegrzyn, Joanna; Potla, Ramesh; Chwae, Yong Joon; Sepuri, Naresh B V; Zhang, Qifang; Koeck, Thomas; Derecka, Marta; Szczepanek, Karol; Szelag, Magdalena; Gornicka, Agnieszka; Moh, Akira; Moghaddas, Shadi; Chen, Qun; Bobbili, Santha; Cichy, Joanna; Dulak, Jozef; Baker, Darren P.; Wolfman, Alan; Stuehr, Dennis; Hassan, Medhat O.; Fu, Xin Yuan; Avadhani, Narayan; Drake, Jennifer I.; Fawcett, Paul; Lesnefsky, Edward J.; Larner, Andrew C.

In: Science, Vol. 323, No. 5915, 06.02.2009, p. 793-797.

Research output: Contribution to journalArticle

Wegrzyn, J, Potla, R, Chwae, YJ, Sepuri, NBV, Zhang, Q, Koeck, T, Derecka, M, Szczepanek, K, Szelag, M, Gornicka, A, Moh, A, Moghaddas, S, Chen, Q, Bobbili, S, Cichy, J, Dulak, J, Baker, DP, Wolfman, A, Stuehr, D, Hassan, MO, Fu, XY, Avadhani, N, Drake, JI, Fawcett, P, Lesnefsky, EJ & Larner, AC 2009, 'Function of mitochondrial Stat3 in cellular respiration', Science, vol. 323, no. 5915, pp. 793-797. https://doi.org/10.1126/science.1164551
Wegrzyn J, Potla R, Chwae YJ, Sepuri NBV, Zhang Q, Koeck T et al. Function of mitochondrial Stat3 in cellular respiration. Science. 2009 Feb 6;323(5915):793-797. https://doi.org/10.1126/science.1164551
Wegrzyn, Joanna ; Potla, Ramesh ; Chwae, Yong Joon ; Sepuri, Naresh B V ; Zhang, Qifang ; Koeck, Thomas ; Derecka, Marta ; Szczepanek, Karol ; Szelag, Magdalena ; Gornicka, Agnieszka ; Moh, Akira ; Moghaddas, Shadi ; Chen, Qun ; Bobbili, Santha ; Cichy, Joanna ; Dulak, Jozef ; Baker, Darren P. ; Wolfman, Alan ; Stuehr, Dennis ; Hassan, Medhat O. ; Fu, Xin Yuan ; Avadhani, Narayan ; Drake, Jennifer I. ; Fawcett, Paul ; Lesnefsky, Edward J. ; Larner, Andrew C. / Function of mitochondrial Stat3 in cellular respiration. In: Science. 2009 ; Vol. 323, No. 5915. pp. 793-797.
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AU - Koeck, Thomas

AU - Derecka, Marta

AU - Szczepanek, Karol

AU - Szelag, Magdalena

AU - Gornicka, Agnieszka

AU - Moh, Akira

AU - Moghaddas, Shadi

AU - Chen, Qun

AU - Bobbili, Santha

AU - Cichy, Joanna

AU - Dulak, Jozef

AU - Baker, Darren P.

AU - Wolfman, Alan

AU - Stuehr, Dennis

AU - Hassan, Medhat O.

AU - Fu, Xin Yuan

AU - Avadhani, Narayan

AU - Drake, Jennifer I.

AU - Fawcett, Paul

AU - Lesnefsky, Edward J.

AU - Larner, Andrew C.

PY - 2009/2/6

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