Function of mitochondrial Stat3 in cellular respiration

Joanna Wegrzyn, Ramesh Potla, Yong Joon Chwae, Naresh B.V. Sepuri, Qifang Zhang, Thomas Koeck, Marta Derecka, Karol Szczepanek, Magdalena Szelag, Agnieszka Gornicka, Akira Moh, Shadi Moghaddas, Qun Chen, Santha Bobbili, Joanna Cichy, Jozef Dulak, Darren P. Baker, Alan Wolfman, Dennis Stuehr, Medhat O. HassanXin Yuan Fu, Narayan Avadhani, Jennifer I. Drake, Paul Fawcett, Edward J. Lesnefsky, Andrew C. Larner

Research output: Contribution to journalArticle

544 Scopus citations

Abstract

Cytokines such as interleukin-6 induce tyrosine and serine phosphorylation of Stat3 that results in activation of Stat3-responsive genes. We provide evidence that Stat3 is present in the mitochondria of cultured cells and primary tissues, including the liver and heart. In Stat3-/- cells, the activities of complexes I and II of the electron transport chain (ETC) were significantly decreased. We identified Stat3 mutants that selectively restored the protein's function as a transcription factor or its functions within the ETC. In mice that do not express Stat3 in the heart, there were also selective defects in the activities of complexes I and II of the ETC. These data indicate that Stat3 is required for optimal function of the ETC, which may allow it to orchestrate responses to cellular homeostasis.

Original languageEnglish (US)
Pages (from-to)793-797
Number of pages5
JournalScience
Volume323
Issue number5915
DOIs
StatePublished - Feb 6 2009

ASJC Scopus subject areas

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    Wegrzyn, J., Potla, R., Chwae, Y. J., Sepuri, N. B. V., Zhang, Q., Koeck, T., Derecka, M., Szczepanek, K., Szelag, M., Gornicka, A., Moh, A., Moghaddas, S., Chen, Q., Bobbili, S., Cichy, J., Dulak, J., Baker, D. P., Wolfman, A., Stuehr, D., ... Larner, A. C. (2009). Function of mitochondrial Stat3 in cellular respiration. Science, 323(5915), 793-797. https://doi.org/10.1126/science.1164551