Functional differentiation of medial temporal and frontal regions involved in processing novel and familiar words

An fMRI study

Andrew Saykin, Sterling C. Johnson, Laura A. Flashman, Thomas W. McAllister, Molly Sparling, Terrance M. Darcey, Chad H. Moritz, Stephen J. Guerin, John Weaver, Alexander Mamourian

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Results of recent functional magnetic resonance imaging (fMRI) studies of memory are not entirely consistent with lesion studies. Furthermore, although imaging probes have identified neural systems associated with processing novel visual episodic information, auditory verbal memory using a novel/familiar paradigm has not yet been examined. To address this gap, fMRI was used to compare the haemodynamic response when listening to recently learned and novel words. Sixteen healthy adults (6 male, 10 female) learned a 10-item word list to 100% criterion, ~1 h before functional scanning. During echo-planar imaging, subjects passively listened to a string of words presented at 6-s intervals. Previously learned words were interspersed pseudo-randomly between novel words. Mean scans corresponding to each word type were analysed with a random-effects model using statistical parametric mapping (SPM96). Familiar (learned) words activated the right prefrontal cortex, posterior left parahippocampal gyrus, left medial parietal cortex and right superior temporal gyrus. Novel words activated the anterior left hippocampal region. The results for the familiar words were similar to those found in other functional imaging studies of recognition and retrieval and implicate the right dorsolateral prefrontal and left posterior medial temporal lobe (MTL) regions. The results for novel words require replication, but are consistent with the substantial lesion and PET literature implicating the anterior MTL as a critical site for processing novel episodic information, presumably to permit encoding. Together, these results provide evidence for an anterior-posterior functional differentiation within the MTL in processing novel and familiar verbal information. The differentiation of MTL functions that was obtained is consistent with a large body of PET activation studies but is unique among fMRI studies, which to date have differed from results with PET. Further, the finding of left MTL lateralization is consistent with lesion-based material-specific models of memory.

Original languageEnglish (US)
Pages (from-to)1963-1971
Number of pages9
JournalBrain
Volume122
Issue number10
DOIs
StatePublished - Oct 1999
Externally publishedYes

Fingerprint

Temporal Lobe
Magnetic Resonance Imaging
Echo-Planar Imaging
Parahippocampal Gyrus
Parietal Lobe
Statistical Models
Prefrontal Cortex
Hemodynamics

Keywords

  • Episodic memory
  • fMRI
  • Hippocampus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Saykin, A., Johnson, S. C., Flashman, L. A., McAllister, T. W., Sparling, M., Darcey, T. M., ... Mamourian, A. (1999). Functional differentiation of medial temporal and frontal regions involved in processing novel and familiar words: An fMRI study. Brain, 122(10), 1963-1971. https://doi.org/10.1093/brain/122.10.1963

Functional differentiation of medial temporal and frontal regions involved in processing novel and familiar words : An fMRI study. / Saykin, Andrew; Johnson, Sterling C.; Flashman, Laura A.; McAllister, Thomas W.; Sparling, Molly; Darcey, Terrance M.; Moritz, Chad H.; Guerin, Stephen J.; Weaver, John; Mamourian, Alexander.

In: Brain, Vol. 122, No. 10, 10.1999, p. 1963-1971.

Research output: Contribution to journalArticle

Saykin, A, Johnson, SC, Flashman, LA, McAllister, TW, Sparling, M, Darcey, TM, Moritz, CH, Guerin, SJ, Weaver, J & Mamourian, A 1999, 'Functional differentiation of medial temporal and frontal regions involved in processing novel and familiar words: An fMRI study', Brain, vol. 122, no. 10, pp. 1963-1971. https://doi.org/10.1093/brain/122.10.1963
Saykin, Andrew ; Johnson, Sterling C. ; Flashman, Laura A. ; McAllister, Thomas W. ; Sparling, Molly ; Darcey, Terrance M. ; Moritz, Chad H. ; Guerin, Stephen J. ; Weaver, John ; Mamourian, Alexander. / Functional differentiation of medial temporal and frontal regions involved in processing novel and familiar words : An fMRI study. In: Brain. 1999 ; Vol. 122, No. 10. pp. 1963-1971.
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