Functional impairment of CD4 T cells despite normalization of T cell number in HIV

Kenneth S. Knox, Richard B. Day, Lisa M. Kohli, Chadi Hage, Homer Twigg

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Using an in vitro model, we demonstrate that when CD4 T cells from HIV infected subjects are enriched from total blood lymphocytes the immune response to antigen is augmented. However, augmentation of this response is confined to HIV infected subjects with relatively preserved CD4 T cell counts. Enriching for CD4 T cells had no effect on antigen responses in patients with low CD4 lymphocyte counts. These findings support the concept that CD4 T cells in late stage HIV have inherent qualitative defects.

Original languageEnglish
Pages (from-to)46-51
Number of pages6
JournalCellular Immunology
Volume242
Issue number1
DOIs
StatePublished - Jul 2006

Fingerprint

Cell Count
HIV
T-Lymphocytes
CD4 Lymphocyte Count
Histocompatibility Antigens Class II
Lymphocytes
Antigens

Keywords

  • CD4
  • HIV
  • Lymphocyte
  • Memory
  • Mumps
  • Proliferation
  • Tetanus

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Functional impairment of CD4 T cells despite normalization of T cell number in HIV. / Knox, Kenneth S.; Day, Richard B.; Kohli, Lisa M.; Hage, Chadi; Twigg, Homer.

In: Cellular Immunology, Vol. 242, No. 1, 07.2006, p. 46-51.

Research output: Contribution to journalArticle

Knox, Kenneth S. ; Day, Richard B. ; Kohli, Lisa M. ; Hage, Chadi ; Twigg, Homer. / Functional impairment of CD4 T cells despite normalization of T cell number in HIV. In: Cellular Immunology. 2006 ; Vol. 242, No. 1. pp. 46-51.
@article{e473d20c0bc04ab88562e41e5e6f3b56,
title = "Functional impairment of CD4 T cells despite normalization of T cell number in HIV",
abstract = "Using an in vitro model, we demonstrate that when CD4 T cells from HIV infected subjects are enriched from total blood lymphocytes the immune response to antigen is augmented. However, augmentation of this response is confined to HIV infected subjects with relatively preserved CD4 T cell counts. Enriching for CD4 T cells had no effect on antigen responses in patients with low CD4 lymphocyte counts. These findings support the concept that CD4 T cells in late stage HIV have inherent qualitative defects.",
keywords = "CD4, HIV, Lymphocyte, Memory, Mumps, Proliferation, Tetanus",
author = "Knox, {Kenneth S.} and Day, {Richard B.} and Kohli, {Lisa M.} and Chadi Hage and Homer Twigg",
year = "2006",
month = "7",
doi = "10.1016/j.cellimm.2006.09.003",
language = "English",
volume = "242",
pages = "46--51",
journal = "Cellular Immunology",
issn = "0008-8749",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Functional impairment of CD4 T cells despite normalization of T cell number in HIV

AU - Knox, Kenneth S.

AU - Day, Richard B.

AU - Kohli, Lisa M.

AU - Hage, Chadi

AU - Twigg, Homer

PY - 2006/7

Y1 - 2006/7

N2 - Using an in vitro model, we demonstrate that when CD4 T cells from HIV infected subjects are enriched from total blood lymphocytes the immune response to antigen is augmented. However, augmentation of this response is confined to HIV infected subjects with relatively preserved CD4 T cell counts. Enriching for CD4 T cells had no effect on antigen responses in patients with low CD4 lymphocyte counts. These findings support the concept that CD4 T cells in late stage HIV have inherent qualitative defects.

AB - Using an in vitro model, we demonstrate that when CD4 T cells from HIV infected subjects are enriched from total blood lymphocytes the immune response to antigen is augmented. However, augmentation of this response is confined to HIV infected subjects with relatively preserved CD4 T cell counts. Enriching for CD4 T cells had no effect on antigen responses in patients with low CD4 lymphocyte counts. These findings support the concept that CD4 T cells in late stage HIV have inherent qualitative defects.

KW - CD4

KW - HIV

KW - Lymphocyte

KW - Memory

KW - Mumps

KW - Proliferation

KW - Tetanus

UR - http://www.scopus.com/inward/record.url?scp=33845450189&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845450189&partnerID=8YFLogxK

U2 - 10.1016/j.cellimm.2006.09.003

DO - 10.1016/j.cellimm.2006.09.003

M3 - Article

VL - 242

SP - 46

EP - 51

JO - Cellular Immunology

JF - Cellular Immunology

SN - 0008-8749

IS - 1

ER -