Functional magnetic resonance imaging of executive control in bipolar disorder

Robert M. Roth, Nancy S. Koven, John J. Randolph, Laura A. Flashman, Heather S. Pixley, Sarah M. Ricketts, Heather A. Wishart, Andrew Saykin

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Bipolar disorder has been associated with dysfunction of executive control processes. Using functional magnetic resonance imaging, we examined brain activation during a counting Stroop task in 11 healthy adults and 11 patients with bipolar I disorder. Results revealed greater activation for the healthy than bipolar disorder group in distributed brain regions that included the right inferior and medial frontal gyri. With the exception of one area within the left posterior cingulate gyrus that was correlated with mania severity, regional activations where group differences were observed were not associated with mood symptoms in the patient group. These findings add to the growing body of evidence implicating neural circuitry subserving executive control in bipolar disorder.

Original languageEnglish (US)
Pages (from-to)1085-1089
Number of pages5
JournalNeuroReport
Volume17
Issue number11
DOIs
StatePublished - Jul 2006
Externally publishedYes

Fingerprint

Executive Function
Bipolar Disorder
Magnetic Resonance Imaging
Prefrontal Cortex
Gyrus Cinguli
Brain

Keywords

  • Bipolar disorder
  • Executive function
  • Frontal lobe
  • Imaging

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Roth, R. M., Koven, N. S., Randolph, J. J., Flashman, L. A., Pixley, H. S., Ricketts, S. M., ... Saykin, A. (2006). Functional magnetic resonance imaging of executive control in bipolar disorder. NeuroReport, 17(11), 1085-1089. https://doi.org/10.1097/01.wnr.0000227979.06013.57

Functional magnetic resonance imaging of executive control in bipolar disorder. / Roth, Robert M.; Koven, Nancy S.; Randolph, John J.; Flashman, Laura A.; Pixley, Heather S.; Ricketts, Sarah M.; Wishart, Heather A.; Saykin, Andrew.

In: NeuroReport, Vol. 17, No. 11, 07.2006, p. 1085-1089.

Research output: Contribution to journalArticle

Roth, RM, Koven, NS, Randolph, JJ, Flashman, LA, Pixley, HS, Ricketts, SM, Wishart, HA & Saykin, A 2006, 'Functional magnetic resonance imaging of executive control in bipolar disorder', NeuroReport, vol. 17, no. 11, pp. 1085-1089. https://doi.org/10.1097/01.wnr.0000227979.06013.57
Roth RM, Koven NS, Randolph JJ, Flashman LA, Pixley HS, Ricketts SM et al. Functional magnetic resonance imaging of executive control in bipolar disorder. NeuroReport. 2006 Jul;17(11):1085-1089. https://doi.org/10.1097/01.wnr.0000227979.06013.57
Roth, Robert M. ; Koven, Nancy S. ; Randolph, John J. ; Flashman, Laura A. ; Pixley, Heather S. ; Ricketts, Sarah M. ; Wishart, Heather A. ; Saykin, Andrew. / Functional magnetic resonance imaging of executive control in bipolar disorder. In: NeuroReport. 2006 ; Vol. 17, No. 11. pp. 1085-1089.
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