Functional magnetic resonance imaging of the primary somatosensory cortex in piglets

Ann Christine Duhaime, Andrew Saykin, Brenna McDonald, Carter P. Dodge, Clifford J. Eskey, Terrance M. Darcey, Loretta L. Grate, Paul Tomashosky

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Object. The piglet is an excellent model for the developing human brain, and has been used increasingly in various centers for studies of traumatic brain injury and other insults. Unlike rodent or primate models, however, there are few behavioral scales for the piglet, and the available ones are used to test general responsiveness rather than specific functional outcome. The differing behavioral repertoires of animals of different ages provide an additional challenge when age-dependent injury responses are compared. To overcome these experimental limitations of piglets in brain injury research, the authors developed a functional magnetic resonance (fMR) imaging paradigm that can be used to track recovery in the somatosensory cortex over time in anesthetized animals of different ages. Methods. Fifteen fMR imaging studies in eight piglets were performed before and after scaled cortical impact injury to the primary somatosensory cortex subserving snout sensation. Specific anesthetic and imaging protocols enabled visualization of cortical activation, and comparison with somatosensory evoked potentials obtained before and after injury was obtained. A piglet brain template for group-level analysis of these data was constructed, similar to the fMR imaging techniques used in humans, to allow for group comparisons and longitudinal change analysis over time. Conclusions. Loss of function in a specifically traumatized cortical region and its subsequent recovery over time can now be demonstrated visually by fMR imaging in the piglet. Besides its value in understanding intrinsic recovery mechanisms and plasticity at different ages, this functional outcome measure will enable the use of the piglet model in treatment trials specifically designed for the immature brain.

Original languageEnglish (US)
Pages (from-to)259-264
Number of pages6
JournalJournal of Neurosurgery
Volume104 PEDIATRICS
Issue numberSUPPL. 4
StatePublished - Apr 2006
Externally publishedYes

Fingerprint

Somatosensory Cortex
Magnetic Resonance Imaging
Wounds and Injuries
Brain
Somatosensory Evoked Potentials
Brain Injuries
Primates
Anesthetics
Rodentia
Outcome Assessment (Health Care)
Research
Therapeutics

Keywords

  • Animal model
  • Brain injury
  • Functional magnetic resonance imaging
  • Pediatric neurosurgery
  • Pig
  • Somatosensory cortex
  • Trauma

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Duhaime, A. C., Saykin, A., McDonald, B., Dodge, C. P., Eskey, C. J., Darcey, T. M., ... Tomashosky, P. (2006). Functional magnetic resonance imaging of the primary somatosensory cortex in piglets. Journal of Neurosurgery, 104 PEDIATRICS(SUPPL. 4), 259-264.

Functional magnetic resonance imaging of the primary somatosensory cortex in piglets. / Duhaime, Ann Christine; Saykin, Andrew; McDonald, Brenna; Dodge, Carter P.; Eskey, Clifford J.; Darcey, Terrance M.; Grate, Loretta L.; Tomashosky, Paul.

In: Journal of Neurosurgery, Vol. 104 PEDIATRICS, No. SUPPL. 4, 04.2006, p. 259-264.

Research output: Contribution to journalArticle

Duhaime, AC, Saykin, A, McDonald, B, Dodge, CP, Eskey, CJ, Darcey, TM, Grate, LL & Tomashosky, P 2006, 'Functional magnetic resonance imaging of the primary somatosensory cortex in piglets', Journal of Neurosurgery, vol. 104 PEDIATRICS, no. SUPPL. 4, pp. 259-264.
Duhaime AC, Saykin A, McDonald B, Dodge CP, Eskey CJ, Darcey TM et al. Functional magnetic resonance imaging of the primary somatosensory cortex in piglets. Journal of Neurosurgery. 2006 Apr;104 PEDIATRICS(SUPPL. 4):259-264.
Duhaime, Ann Christine ; Saykin, Andrew ; McDonald, Brenna ; Dodge, Carter P. ; Eskey, Clifford J. ; Darcey, Terrance M. ; Grate, Loretta L. ; Tomashosky, Paul. / Functional magnetic resonance imaging of the primary somatosensory cortex in piglets. In: Journal of Neurosurgery. 2006 ; Vol. 104 PEDIATRICS, No. SUPPL. 4. pp. 259-264.
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