Functional MRI localisation of central nervous system regions associated with volitional inspiration in humans

Karleyton C. Evans, Steven A. Shea, Andrew Saykin

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

1. Functional magnetic resonance imaging (fMRI) provides a means of studying neuronal circuits that control respiratory muscles in humans with better spatial and temporal resolution than in previous positron emission tomography (PET) studies. 2. Whole brain blood oxygenation level-dependent (BOLD) changes determined by fMRI were used to identify areas of neuronal activation associated with volitional inspiration in five healthy men. Four series of scans of each subject were acquired during voluntary breathing (active task) and mechanical ventilation (passive task). Ventilation and end-tidal P(CO2) were similar between tasks. Scan data were re-aligned to correct for movement artefacts and cross-referenced breath by breath to respiratory data for selective averaging of inspiratory and expiratory images. 3. Group analysis identified significant increases in the fMRI signal with volitional inspiration in the superior motor cortex, premotor cortex and supplementary motor area at loci similar to those detected in earlier studies that used PET. Additional regions activated by volitional inspiration included inferolateral sensorimotor cortex, prefrontal cortex and striatum (these foci were only revealed by PET under significant inspiratory load). 4. This study represents the first synchronised breath-by-breath analysis of respiratory-related neuronal activity with whole brain imaging in humans. Temporal resolution is sufficient to distinguish individual breaths at a normal breathing frequency.

Original languageEnglish (US)
Pages (from-to)383-392
Number of pages10
JournalJournal of Physiology
Volume520
Issue number2
DOIs
StatePublished - Oct 15 1999
Externally publishedYes

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Motor Cortex
Positron-Emission Tomography
Central Nervous System
Magnetic Resonance Imaging
Respiration
Respiratory Muscles
Prefrontal Cortex
Artificial Respiration
Neuroimaging
Artifacts
Ventilation
Brain

ASJC Scopus subject areas

  • Physiology

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Functional MRI localisation of central nervous system regions associated with volitional inspiration in humans. / Evans, Karleyton C.; Shea, Steven A.; Saykin, Andrew.

In: Journal of Physiology, Vol. 520, No. 2, 15.10.1999, p. 383-392.

Research output: Contribution to journalArticle

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