Functional MRI of mild traumatic brain injury (mTBI): Progress and perspectives from the first decade of studies

Brenna McDonald, Andrew Saykin, Thomas W. McAllister

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Mild traumatic brain injury (mTBI) represents the great majority of traumatic brain injuries, and is a common medical problem affecting cognitive and vocational functioning as well as quality of life in some individuals. Functional MRI (fMRI) is an important research method for investigating the neuroanatomic substrates of cognitive disorders and their treatment. Surprisingly, however, relatively little research has utilized fMRI to examine alterations in brain functioning after mTBI. This article provides a critical overview of the published fMRI research on mTBI to date. These topics include examination of frontal lobe/executive functions such as working memory, as well as episodic memory and resting state/functional connectivity. mTBI has also been investigated in military populations where studies have focused on effects of blast injury and comorbid conditions such as post-traumatic stress disorder and major depressive disorder. Finally, we address fMRI evaluations of response to behavioral or pharmacological challenges and interventions targeting cognitive and behavioral sequelae of mTBI. The review concludes with identification and discussion of gaps in current knowledge and future directions for fMRI studies of mTBI. The authors conclude that fMRI in combination with related methods can be expected to play an increasing role in research related to studies of pathophysiological mechanisms of the sequelae of mTBI as well as in diagnosis and treatment monitoring.

Original languageEnglish
Pages (from-to)193-207
Number of pages15
JournalBrain Imaging and Behavior
Volume6
Issue number2
DOIs
StatePublished - Jun 2012

Fingerprint

Brain Concussion
Magnetic Resonance Imaging
Research
Blast Injuries
Episodic Memory
Executive Function
Major Depressive Disorder
Frontal Lobe
Post-Traumatic Stress Disorders
Short-Term Memory
Quality of Life
Pharmacology
Brain

Keywords

  • Episodic memory
  • Frontal lobes
  • Functional connectivity
  • Functional MRI
  • Mild traumatic brain injury
  • Working memory

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience
  • Behavioral Neuroscience
  • Radiology Nuclear Medicine and imaging

Cite this

Functional MRI of mild traumatic brain injury (mTBI) : Progress and perspectives from the first decade of studies. / McDonald, Brenna; Saykin, Andrew; McAllister, Thomas W.

In: Brain Imaging and Behavior, Vol. 6, No. 2, 06.2012, p. 193-207.

Research output: Contribution to journalArticle

@article{f377aba1d77e4abcb455bae9dea4f451,
title = "Functional MRI of mild traumatic brain injury (mTBI): Progress and perspectives from the first decade of studies",
abstract = "Mild traumatic brain injury (mTBI) represents the great majority of traumatic brain injuries, and is a common medical problem affecting cognitive and vocational functioning as well as quality of life in some individuals. Functional MRI (fMRI) is an important research method for investigating the neuroanatomic substrates of cognitive disorders and their treatment. Surprisingly, however, relatively little research has utilized fMRI to examine alterations in brain functioning after mTBI. This article provides a critical overview of the published fMRI research on mTBI to date. These topics include examination of frontal lobe/executive functions such as working memory, as well as episodic memory and resting state/functional connectivity. mTBI has also been investigated in military populations where studies have focused on effects of blast injury and comorbid conditions such as post-traumatic stress disorder and major depressive disorder. Finally, we address fMRI evaluations of response to behavioral or pharmacological challenges and interventions targeting cognitive and behavioral sequelae of mTBI. The review concludes with identification and discussion of gaps in current knowledge and future directions for fMRI studies of mTBI. The authors conclude that fMRI in combination with related methods can be expected to play an increasing role in research related to studies of pathophysiological mechanisms of the sequelae of mTBI as well as in diagnosis and treatment monitoring.",
keywords = "Episodic memory, Frontal lobes, Functional connectivity, Functional MRI, Mild traumatic brain injury, Working memory",
author = "Brenna McDonald and Andrew Saykin and McAllister, {Thomas W.}",
year = "2012",
month = "6",
doi = "10.1007/s11682-012-9173-4",
language = "English",
volume = "6",
pages = "193--207",
journal = "Brain Imaging and Behavior",
issn = "1931-7557",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - Functional MRI of mild traumatic brain injury (mTBI)

T2 - Progress and perspectives from the first decade of studies

AU - McDonald, Brenna

AU - Saykin, Andrew

AU - McAllister, Thomas W.

PY - 2012/6

Y1 - 2012/6

N2 - Mild traumatic brain injury (mTBI) represents the great majority of traumatic brain injuries, and is a common medical problem affecting cognitive and vocational functioning as well as quality of life in some individuals. Functional MRI (fMRI) is an important research method for investigating the neuroanatomic substrates of cognitive disorders and their treatment. Surprisingly, however, relatively little research has utilized fMRI to examine alterations in brain functioning after mTBI. This article provides a critical overview of the published fMRI research on mTBI to date. These topics include examination of frontal lobe/executive functions such as working memory, as well as episodic memory and resting state/functional connectivity. mTBI has also been investigated in military populations where studies have focused on effects of blast injury and comorbid conditions such as post-traumatic stress disorder and major depressive disorder. Finally, we address fMRI evaluations of response to behavioral or pharmacological challenges and interventions targeting cognitive and behavioral sequelae of mTBI. The review concludes with identification and discussion of gaps in current knowledge and future directions for fMRI studies of mTBI. The authors conclude that fMRI in combination with related methods can be expected to play an increasing role in research related to studies of pathophysiological mechanisms of the sequelae of mTBI as well as in diagnosis and treatment monitoring.

AB - Mild traumatic brain injury (mTBI) represents the great majority of traumatic brain injuries, and is a common medical problem affecting cognitive and vocational functioning as well as quality of life in some individuals. Functional MRI (fMRI) is an important research method for investigating the neuroanatomic substrates of cognitive disorders and their treatment. Surprisingly, however, relatively little research has utilized fMRI to examine alterations in brain functioning after mTBI. This article provides a critical overview of the published fMRI research on mTBI to date. These topics include examination of frontal lobe/executive functions such as working memory, as well as episodic memory and resting state/functional connectivity. mTBI has also been investigated in military populations where studies have focused on effects of blast injury and comorbid conditions such as post-traumatic stress disorder and major depressive disorder. Finally, we address fMRI evaluations of response to behavioral or pharmacological challenges and interventions targeting cognitive and behavioral sequelae of mTBI. The review concludes with identification and discussion of gaps in current knowledge and future directions for fMRI studies of mTBI. The authors conclude that fMRI in combination with related methods can be expected to play an increasing role in research related to studies of pathophysiological mechanisms of the sequelae of mTBI as well as in diagnosis and treatment monitoring.

KW - Episodic memory

KW - Frontal lobes

KW - Functional connectivity

KW - Functional MRI

KW - Mild traumatic brain injury

KW - Working memory

UR - http://www.scopus.com/inward/record.url?scp=84863323094&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863323094&partnerID=8YFLogxK

U2 - 10.1007/s11682-012-9173-4

DO - 10.1007/s11682-012-9173-4

M3 - Article

C2 - 22618832

AN - SCOPUS:84863323094

VL - 6

SP - 193

EP - 207

JO - Brain Imaging and Behavior

JF - Brain Imaging and Behavior

SN - 1931-7557

IS - 2

ER -