In the human brain, functionally and anatomically defined systems exist for encoding, consolidating, and retrieving memories of experiences (episodic memory); accumulating and accessing factual information in a body of knowledge (semantic memory); and actively processing and manipulating information (working memory). These three memory systems can be distinguished from other nondeclarative memory systems such as procedural learning and priming [1-4]. Brain-behavior studies using a variety of approaches from lesion-based research to functional magnetic resonance imaging (fMRI) demonstrate distinct though highly interrelated neural circuitry for episodic, semantic, and working memory [3, 5]. Each of these memory systems, despite their close interaction, is affected somewhat differently by aging and dementia.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)