Functional neuroanatomical correlates of episodic memory impairment in early phase psychosis

Michael Matthew Francis, Tom A. Hummer, Jenifer Vohs, Matthew G. Yung, Emily Liffick, Nicole F. Mehdiyoun, Alexander Radnovich, Brenna McDonald, Andrew Saykin, Alan Breier

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Studies have demonstrated that episodic memory (EM) is often preferentially disrupted in schizophrenia. The neural substrates that mediate EM impairment in this illness are not fully understood. Several functional magnetic resonance imaging (fMRI) studies have employed EM probe tasks to elucidate the neural underpinnings of impairment, though results have been inconsistent. The majority of EM imaging studies have been conducted in chronic forms of schizophrenia with relatively few studies in early phase patients. Early phase schizophrenia studies are important because they may provide information regarding when EM deficits occur and address potential confounds more frequently observed in chronic populations. In this study, we assessed brain activation during the performance of visual scene encoding and recognition fMRI tasks in patients with earlyphase psychosis (n = 35) and age, sex, and race matched healthy control subjects (n = 20). Patients demonstrated significantly lower activation than controls in the right hippocampus and left fusiform gyrus during scene encoding and lower activation in the posterior cingulate, precuneus, and left middle temporal cortex during recognition of target scenes. Symptom levels were not related to the imaging findings, though better cognitive performance in patients was associated with greater right hippocampal activation during encoding. These results provide evidence of altered function in neuroanatomical circuitry subserving EM early in the course of psychotic illness, which may have implications for pathophysiological models of this illness.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalBrain Imaging and Behavior
Volume10
Issue number1
DOIs
StatePublished - Mar 1 2016

Fingerprint

Episodic Memory
Psychotic Disorders
Schizophrenia
Temporal Lobe
Magnetic Resonance Imaging
Parietal Lobe
Gyrus Cinguli
Memory Disorders
Hippocampus
Healthy Volunteers
Brain
Population

Keywords

  • Cognition
  • Early phase psychosis
  • Encoding
  • Episodic memory
  • fMRI
  • Recognition

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Behavioral Neuroscience
  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience
  • Neurology
  • Psychiatry and Mental health
  • Clinical Neurology

Cite this

Functional neuroanatomical correlates of episodic memory impairment in early phase psychosis. / Francis, Michael Matthew; Hummer, Tom A.; Vohs, Jenifer; Yung, Matthew G.; Liffick, Emily; Mehdiyoun, Nicole F.; Radnovich, Alexander; McDonald, Brenna; Saykin, Andrew; Breier, Alan.

In: Brain Imaging and Behavior, Vol. 10, No. 1, 01.03.2016, p. 1-11.

Research output: Contribution to journalArticle

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