Functional recovery after facial nerve crush is delayed in severe combined immunodeficient mice

Craig J. Serpe, Julie E. Tetzlaff, Susanna Coers, Virginia M. Sanders, Kathryn Jones

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The goal of the current study was to determine if T and B lymphocytes play a role in functional recovery after peripheral nerve injury. The time course of behavioral recovery following facial nerve crush injury at the stylomastoid foramen was established in scid mice which lack functional T and B cells and reconstituted scid mice as compared to wild-type mice. The average time necessary for recovery of full eye blink reflex and vibrissae movements in wild-type mice was 10.3 ± 0.2 and 9.9 ± 0.34 days, respectively. In contrast, recovery of full eye blink reflex and vibrissae movements took 14.8 ± 0.54 and 12.3 ± 0.41 days, respectively, in scid mice. Reconstitution of scid mice with whole splenocytes resulted in functional recovery times similar to wild-type, with eye blink reflex recovery and vibrissae movement being 10.5 ± 0.3 and 10.0 ± 0.0 days, respectively. These results suggest that the delayed behavioral recovery time observed in scid mice may be due to the absence of T and B lymphocytes.

Original languageEnglish (US)
Pages (from-to)808-812
Number of pages5
JournalBrain, Behavior, and Immunity
Volume16
Issue number6
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Nerve Crush
SCID Mice
Facial Nerve
Vibrissae
Blinking
B-Lymphocytes
T-Lymphocytes
Facial Nerve Injuries
Peripheral Nerve Injuries

Keywords

  • Facial nerve crush
  • Functional recover
  • Neuroimmune interactions
  • Neuronal survival
  • scid
  • T and B Lymphocytes

ASJC Scopus subject areas

  • Immunology
  • Behavioral Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Functional recovery after facial nerve crush is delayed in severe combined immunodeficient mice. / Serpe, Craig J.; Tetzlaff, Julie E.; Coers, Susanna; Sanders, Virginia M.; Jones, Kathryn.

In: Brain, Behavior, and Immunity, Vol. 16, No. 6, 2002, p. 808-812.

Research output: Contribution to journalArticle

Serpe, Craig J. ; Tetzlaff, Julie E. ; Coers, Susanna ; Sanders, Virginia M. ; Jones, Kathryn. / Functional recovery after facial nerve crush is delayed in severe combined immunodeficient mice. In: Brain, Behavior, and Immunity. 2002 ; Vol. 16, No. 6. pp. 808-812.
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