Functional status and quality of life among breast cancer survivors with heart failure: results of the Medicare Health Outcomes Survey

Jordan M. Harrison, Matthew A. Davis, Debra L. Barton, Nancy K. Janz, Susan Pressler, Christopher R. Friese

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: The purpose of this population-based study was to examine health-related quality of life (HRQOL) and functional status among breast cancer survivors with heart failure. Methods: We examined Medicare Health Outcomes Survey data from women aged 65 and older diagnosed with breast cancer in the past 5 years. Surveys were linked to Surveillance, Epidemiology, and End Results cancer registries. Each woman identified with self-reported heart failure (n = 239) was matched to controls without heart failure (n = 685) using propensity scores. The Short Form-36/Veterans Rand-12 measured eight domains of HRQOL. Functional status impairment was measured by limitations in six activities of daily living (ADLs). Linear models estimated associations between heart failure status and HRQOL. Logistic regression models estimated odds ratios for associations between heart failure and ADL impairment. We examined associations for the total study population and subgroups stratified by cancer stage. Results: Among all study participants, heart failure was associated with significant deficits in every HRQOL domain and impairment in all ADLs (p < 0.01, ORs ranged from 1.74 to 2.47). After stratification by cancer stage, heart failure was associated with physical HRQOL deficits across all cancer stages (physical function, vitality, general health) and mental HRQOL deficits only in women with stage I/II cancer (role-emotional, social function). Women with early stage cancer experienced the greatest HRQOL deficits associated with heart failure. Conclusions: Heart failure in breast cancer survivors is associated with substantial HRQOL deficits and functional status impairment, particularly in early stage cancer. Tailored interventions are needed to improve physical function and mental wellbeing in this high-risk population.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalSupportive Care in Cancer
DOIs
StateAccepted/In press - Mar 8 2017

Fingerprint

Medicare
Health Surveys
Survivors
Heart Failure
Quality of Life
Breast Neoplasms
Activities of Daily Living
Neoplasms
Logistic Models
Population
Propensity Score
Veterans
Registries
Linear Models
Mental Health
Epidemiology
Odds Ratio
Health

Keywords

  • Breast cancer
  • Cancer survivor
  • Comorbidity
  • Health-related quality of life
  • Heart failure
  • Patient report

ASJC Scopus subject areas

  • Oncology

Cite this

Functional status and quality of life among breast cancer survivors with heart failure : results of the Medicare Health Outcomes Survey. / Harrison, Jordan M.; Davis, Matthew A.; Barton, Debra L.; Janz, Nancy K.; Pressler, Susan; Friese, Christopher R.

In: Supportive Care in Cancer, 08.03.2017, p. 1-11.

Research output: Contribution to journalArticle

Harrison, Jordan M. ; Davis, Matthew A. ; Barton, Debra L. ; Janz, Nancy K. ; Pressler, Susan ; Friese, Christopher R. / Functional status and quality of life among breast cancer survivors with heart failure : results of the Medicare Health Outcomes Survey. In: Supportive Care in Cancer. 2017 ; pp. 1-11.
@article{6f340ea9f5fd422bb4fd8fda6d16ae4e,
title = "Functional status and quality of life among breast cancer survivors with heart failure: results of the Medicare Health Outcomes Survey",
abstract = "Purpose: The purpose of this population-based study was to examine health-related quality of life (HRQOL) and functional status among breast cancer survivors with heart failure. Methods: We examined Medicare Health Outcomes Survey data from women aged 65 and older diagnosed with breast cancer in the past 5 years. Surveys were linked to Surveillance, Epidemiology, and End Results cancer registries. Each woman identified with self-reported heart failure (n = 239) was matched to controls without heart failure (n = 685) using propensity scores. The Short Form-36/Veterans Rand-12 measured eight domains of HRQOL. Functional status impairment was measured by limitations in six activities of daily living (ADLs). Linear models estimated associations between heart failure status and HRQOL. Logistic regression models estimated odds ratios for associations between heart failure and ADL impairment. We examined associations for the total study population and subgroups stratified by cancer stage. Results: Among all study participants, heart failure was associated with significant deficits in every HRQOL domain and impairment in all ADLs (p < 0.01, ORs ranged from 1.74 to 2.47). After stratification by cancer stage, heart failure was associated with physical HRQOL deficits across all cancer stages (physical function, vitality, general health) and mental HRQOL deficits only in women with stage I/II cancer (role-emotional, social function). Women with early stage cancer experienced the greatest HRQOL deficits associated with heart failure. Conclusions: Heart failure in breast cancer survivors is associated with substantial HRQOL deficits and functional status impairment, particularly in early stage cancer. Tailored interventions are needed to improve physical function and mental wellbeing in this high-risk population.",
keywords = "Breast cancer, Cancer survivor, Comorbidity, Health-related quality of life, Heart failure, Patient report",
author = "Harrison, {Jordan M.} and Davis, {Matthew A.} and Barton, {Debra L.} and Janz, {Nancy K.} and Susan Pressler and Friese, {Christopher R.}",
year = "2017",
month = "3",
day = "8",
doi = "10.1007/s00520-017-3653-4",
language = "English (US)",
pages = "1--11",
journal = "Supportive Care in Cancer",
issn = "0941-4355",
publisher = "Springer Verlag",

}

TY - JOUR

T1 - Functional status and quality of life among breast cancer survivors with heart failure

T2 - results of the Medicare Health Outcomes Survey

AU - Harrison, Jordan M.

AU - Davis, Matthew A.

AU - Barton, Debra L.

AU - Janz, Nancy K.

AU - Pressler, Susan

AU - Friese, Christopher R.

PY - 2017/3/8

Y1 - 2017/3/8

N2 - Purpose: The purpose of this population-based study was to examine health-related quality of life (HRQOL) and functional status among breast cancer survivors with heart failure. Methods: We examined Medicare Health Outcomes Survey data from women aged 65 and older diagnosed with breast cancer in the past 5 years. Surveys were linked to Surveillance, Epidemiology, and End Results cancer registries. Each woman identified with self-reported heart failure (n = 239) was matched to controls without heart failure (n = 685) using propensity scores. The Short Form-36/Veterans Rand-12 measured eight domains of HRQOL. Functional status impairment was measured by limitations in six activities of daily living (ADLs). Linear models estimated associations between heart failure status and HRQOL. Logistic regression models estimated odds ratios for associations between heart failure and ADL impairment. We examined associations for the total study population and subgroups stratified by cancer stage. Results: Among all study participants, heart failure was associated with significant deficits in every HRQOL domain and impairment in all ADLs (p < 0.01, ORs ranged from 1.74 to 2.47). After stratification by cancer stage, heart failure was associated with physical HRQOL deficits across all cancer stages (physical function, vitality, general health) and mental HRQOL deficits only in women with stage I/II cancer (role-emotional, social function). Women with early stage cancer experienced the greatest HRQOL deficits associated with heart failure. Conclusions: Heart failure in breast cancer survivors is associated with substantial HRQOL deficits and functional status impairment, particularly in early stage cancer. Tailored interventions are needed to improve physical function and mental wellbeing in this high-risk population.

AB - Purpose: The purpose of this population-based study was to examine health-related quality of life (HRQOL) and functional status among breast cancer survivors with heart failure. Methods: We examined Medicare Health Outcomes Survey data from women aged 65 and older diagnosed with breast cancer in the past 5 years. Surveys were linked to Surveillance, Epidemiology, and End Results cancer registries. Each woman identified with self-reported heart failure (n = 239) was matched to controls without heart failure (n = 685) using propensity scores. The Short Form-36/Veterans Rand-12 measured eight domains of HRQOL. Functional status impairment was measured by limitations in six activities of daily living (ADLs). Linear models estimated associations between heart failure status and HRQOL. Logistic regression models estimated odds ratios for associations between heart failure and ADL impairment. We examined associations for the total study population and subgroups stratified by cancer stage. Results: Among all study participants, heart failure was associated with significant deficits in every HRQOL domain and impairment in all ADLs (p < 0.01, ORs ranged from 1.74 to 2.47). After stratification by cancer stage, heart failure was associated with physical HRQOL deficits across all cancer stages (physical function, vitality, general health) and mental HRQOL deficits only in women with stage I/II cancer (role-emotional, social function). Women with early stage cancer experienced the greatest HRQOL deficits associated with heart failure. Conclusions: Heart failure in breast cancer survivors is associated with substantial HRQOL deficits and functional status impairment, particularly in early stage cancer. Tailored interventions are needed to improve physical function and mental wellbeing in this high-risk population.

KW - Breast cancer

KW - Cancer survivor

KW - Comorbidity

KW - Health-related quality of life

KW - Heart failure

KW - Patient report

UR - http://www.scopus.com/inward/record.url?scp=85014622072&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014622072&partnerID=8YFLogxK

U2 - 10.1007/s00520-017-3653-4

DO - 10.1007/s00520-017-3653-4

M3 - Article

C2 - 28275898

AN - SCOPUS:85014622072

SP - 1

EP - 11

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

SN - 0941-4355

ER -