Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin

Jen C. Wang, Anthony L. Hinrichs, Sarah Bertelsen, Heather Stock, John P. Budde, Danielle M. Dick, Kathleen K. Bucholz, John Rice, Nancy Saccone, Howard Edenberg, Victor Hesselbrock, Samuel Kuperman, Marc A. Schuckit, Laura J. Bierut, Alison M. Goate

Research output: Contribution to journalArticle

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Abstract

Background: A novel family of G protein-coupled receptors, TAS2Rs, has recently been characterized and linked to sensitivity to bitter taste compounds. We have previously reported that a missense mutation in the TAS2R16 gene reduces the sensitivity of the receptor to bitter-taste stimuli and that it is associated with risk for alcohol dependence. Other family-based studies on the genetic transmittance of taste perception have previously demonstrated a correlation between genetic variation in TAS2R38 and sensitivity to bitter-taste compounds such as phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP). Haplotypes resulting from 3 common nonsynonymous coding single-nucleotide polymorphisms in the TAS2R38 gene have been shown to alter receptor functions and taste sensitivity to PTC and PROP. The perceived bitterness of PROP has also been associated with oral sensation and drinking behaviors. Methods: We used family-based association methods to test for association between TAS2R38 haplotypes and alcohol dependence as well as a measure of alcohol consumption (Maxdrinks) and age of onset of drinking behaviors in a sample of families densely affected with alcoholism. We have also extended our analysis of TAS2R16 to include the Maxdrinks phenotype. Results: A positive correlation was observed between TAS2R38 haplotypes and Maxdrinks in Collaborative Study on the Genetics of Alcoholism (COGA) high-risk women of African-American origin. The common taster haplotype is significantly associated with a lower mean Maxdrinks compared with the other haplotypes. Similarly, the allele of TAS2R16 that is associated with a lower risk for alcohol dependence is also associated with lower mean Maxdrinks scores in African-American families. In contrast to the previously reported significant association between TAS2R16 and alcohol dependence, we found no evidence that TAS2R38 haplotypes influence alcohol dependence in the COGA dataset. Conclusion: Functional variants in both TAS2R16 and TAS2R38 correlate with alcohol consumption in African-American families.

Original languageEnglish
Pages (from-to)209-215
Number of pages7
JournalAlcoholism: Clinical and Experimental Research
Volume31
Issue number2
DOIs
StatePublished - Feb 2007

Fingerprint

Alcohol Drinking
African Americans
Alcoholism
Alcohols
Haplotypes
Propylthiouracil
Phenylthiourea
Drinking Behavior
Genes
Taste Perception
G-Protein-Coupled Receptors
Polymorphism
Missense Mutation
Age of Onset
Single Nucleotide Polymorphism
Nucleotides
Alleles
Phenotype

Keywords

  • Alcohol Dependence
  • Maxdrinks
  • TAS2R38 Haplotype

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin. / Wang, Jen C.; Hinrichs, Anthony L.; Bertelsen, Sarah; Stock, Heather; Budde, John P.; Dick, Danielle M.; Bucholz, Kathleen K.; Rice, John; Saccone, Nancy; Edenberg, Howard; Hesselbrock, Victor; Kuperman, Samuel; Schuckit, Marc A.; Bierut, Laura J.; Goate, Alison M.

In: Alcoholism: Clinical and Experimental Research, Vol. 31, No. 2, 02.2007, p. 209-215.

Research output: Contribution to journalArticle

Wang, JC, Hinrichs, AL, Bertelsen, S, Stock, H, Budde, JP, Dick, DM, Bucholz, KK, Rice, J, Saccone, N, Edenberg, H, Hesselbrock, V, Kuperman, S, Schuckit, MA, Bierut, LJ & Goate, AM 2007, 'Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin', Alcoholism: Clinical and Experimental Research, vol. 31, no. 2, pp. 209-215. https://doi.org/10.1111/j.1530-0277.2006.00297.x
Wang, Jen C. ; Hinrichs, Anthony L. ; Bertelsen, Sarah ; Stock, Heather ; Budde, John P. ; Dick, Danielle M. ; Bucholz, Kathleen K. ; Rice, John ; Saccone, Nancy ; Edenberg, Howard ; Hesselbrock, Victor ; Kuperman, Samuel ; Schuckit, Marc A. ; Bierut, Laura J. ; Goate, Alison M. / Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin. In: Alcoholism: Clinical and Experimental Research. 2007 ; Vol. 31, No. 2. pp. 209-215.
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AU - Bertelsen, Sarah

AU - Stock, Heather

AU - Budde, John P.

AU - Dick, Danielle M.

AU - Bucholz, Kathleen K.

AU - Rice, John

AU - Saccone, Nancy

AU - Edenberg, Howard

AU - Hesselbrock, Victor

AU - Kuperman, Samuel

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