Functions of the VEGF receptor-1 (FLT-1) in the vasculature

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Vascular endothelial growth factor (VEGF) is a major inducer of angiogenesis and vasculogenesis. Two distinct receptors for VEGF, the tyrosine kinase receptors VEGFR-1 (Flt-1) and VEGFR-2 (Flk-1/KDR), have been identified. Transfection studies could demonstrate biological activities for the Flk-1/KDR-, but not for the Flt-1-receptor, which led to the hypothesis that Flt-1 is a decoy receptor for VEGF. However, Flt-1 is biologically active in non-endothelial cells, namely monocytes, which exclusively express this receptor. In addition, the Flt-1 ligand placenta growth factor (PlGF), which is unable to bind and activate Flk-1/KDR, elicits activities in both monocytes and endothelial cells. The implications of Flt-1 mediated monocyte transmigration through endothelial monolayers and induction of the procoagulant tissue factor on monocytes for the field of vascular medicine are discussed.

Original languageEnglish (US)
Pages (from-to)241-245
Number of pages5
JournalTrends in Cardiovascular Medicine
Volume8
Issue number6
DOIs
StatePublished - Aug 1998
Externally publishedYes

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Vascular Endothelial Growth Factor Receptor-1
Monocytes
Vascular Endothelial Growth Factor Receptor
Transendothelial and Transepithelial Migration
Vascular Endothelial Growth Factor Receptor-2
Angiogenesis Inducing Agents
Receptor Protein-Tyrosine Kinases
Thromboplastin
Cardiology
Vascular Endothelial Growth Factor A
Transfection
Endothelial Cells
Ligands

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Functions of the VEGF receptor-1 (FLT-1) in the vasculature. / Clauss, Matthias.

In: Trends in Cardiovascular Medicine, Vol. 8, No. 6, 08.1998, p. 241-245.

Research output: Contribution to journalArticle

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