Functions of thymic stromal lymphopoietin in immunity and disease

Yanlu Zhang, Baohua Zhou

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Thymic stromal lymphopoietin (TSLP) is an interleukin 7-like cytokine expressed mainly by epithelial cells. Current studies provide compelling evidence that TSLP is capable of activating dendritic cells to promote T helper (Th) 2 immune responses. TSLP has also been shown to directly promote Th2 differentiation of naïve CD4 + T cell and activate natural killer T cells, basophils and other innate immune cells at the initial stage of inflammation. In addition, TSLP affects B cell maturation and activation and can also influence regulatory T (Treg) cell differentiation and development. TSLP-induced Th2 responses are associated with the pathogenesis of allergic inflammatory diseases, including atopic dermatitis, asthma, and rhinitis. Based on recent findings in humans and mouse models, TSLP might also be involved in the pathogenesis of inflammatory bowel disease and progression of cancer. In this review, we will summarize our current understanding of the biology of TSLP and highlight the important issues for future investigations.

Original languageEnglish (US)
Pages (from-to)211-223
Number of pages13
JournalImmunologic Research
Volume52
Issue number3
DOIs
StatePublished - Jun 1 2012

Keywords

  • Allergy
  • Cancer
  • Inflammation
  • Th2
  • TSLP

ASJC Scopus subject areas

  • Immunology

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