Further analyses of genetic association between GRM8 and alcohol dependence symptoms among young adults

Elizabeth C. Long, Azil Aliev, Jen Chyong Wang, Howard Edenberg, John Nurnberger, Victor Hesselbrock, Bernice Porjesz, Danielle M. Dick

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: The gene GRM8, a metabotropic glutamate receptor, has emerged as a gene of interest for its possible role in the development of alcohol dependence, with evidence of association with an electrophysiological endophenotype and level of response to alcohol as well as suggestive evidence of association with alcohol dependence. Method: The present study further investigated the association between GRM8 and alcohol dependence symptom counts among young adults using a new sample of individuals collected as part of the prospective sample (ages 18–26 years; N = 842) from the Collaborative Study on the Genetics of Alcoholism (COGA). Results: Two single-nucleotide polymorphisms were significantly associated with alcohol dependence in European Americans using the Nyholt corrected p value of .007: rs886003 (β = -.212, p = .0002) and rs17862325 (β = -.234, p < .0001), but not in African Americans, likely because of the lower power to detect association in this group. Conclusions: These results further implicate the role of glutamate receptor genes such as GRM8 in the development of alcohol dependence.

Original languageEnglish
Pages (from-to)414-418
Number of pages5
JournalJournal of Studies on Alcohol and Drugs
Volume76
Issue number3
StatePublished - May 1 2015

Fingerprint

Alcoholism
young adult
Young Adult
alcohol
Alcohols
Genes
Endophenotypes
Metabotropic Glutamate Receptors
Glutamate Receptors
Polymorphism
alcoholism
African Americans
Single Nucleotide Polymorphism
evidence
Nucleotides
Group

ASJC Scopus subject areas

  • Health(social science)
  • Psychiatry and Mental health
  • Toxicology

Cite this

Further analyses of genetic association between GRM8 and alcohol dependence symptoms among young adults. / Long, Elizabeth C.; Aliev, Azil; Wang, Jen Chyong; Edenberg, Howard; Nurnberger, John; Hesselbrock, Victor; Porjesz, Bernice; Dick, Danielle M.

In: Journal of Studies on Alcohol and Drugs, Vol. 76, No. 3, 01.05.2015, p. 414-418.

Research output: Contribution to journalArticle

Long, Elizabeth C. ; Aliev, Azil ; Wang, Jen Chyong ; Edenberg, Howard ; Nurnberger, John ; Hesselbrock, Victor ; Porjesz, Bernice ; Dick, Danielle M. / Further analyses of genetic association between GRM8 and alcohol dependence symptoms among young adults. In: Journal of Studies on Alcohol and Drugs. 2015 ; Vol. 76, No. 3. pp. 414-418.
@article{48f715eef23d47d68b854268f7a51bb2,
title = "Further analyses of genetic association between GRM8 and alcohol dependence symptoms among young adults",
abstract = "Objective: The gene GRM8, a metabotropic glutamate receptor, has emerged as a gene of interest for its possible role in the development of alcohol dependence, with evidence of association with an electrophysiological endophenotype and level of response to alcohol as well as suggestive evidence of association with alcohol dependence. Method: The present study further investigated the association between GRM8 and alcohol dependence symptom counts among young adults using a new sample of individuals collected as part of the prospective sample (ages 18–26 years; N = 842) from the Collaborative Study on the Genetics of Alcoholism (COGA). Results: Two single-nucleotide polymorphisms were significantly associated with alcohol dependence in European Americans using the Nyholt corrected p value of .007: rs886003 (β = -.212, p = .0002) and rs17862325 (β = -.234, p < .0001), but not in African Americans, likely because of the lower power to detect association in this group. Conclusions: These results further implicate the role of glutamate receptor genes such as GRM8 in the development of alcohol dependence.",
author = "Long, {Elizabeth C.} and Azil Aliev and Wang, {Jen Chyong} and Howard Edenberg and John Nurnberger and Victor Hesselbrock and Bernice Porjesz and Dick, {Danielle M.}",
year = "2015",
month = "5",
day = "1",
language = "English",
volume = "76",
pages = "414--418",
journal = "Journal of Studies on Alcohol and Drugs",
issn = "1937-1888",
publisher = "Alcohol Research Documentation, Inc.",
number = "3",

}

TY - JOUR

T1 - Further analyses of genetic association between GRM8 and alcohol dependence symptoms among young adults

AU - Long, Elizabeth C.

AU - Aliev, Azil

AU - Wang, Jen Chyong

AU - Edenberg, Howard

AU - Nurnberger, John

AU - Hesselbrock, Victor

AU - Porjesz, Bernice

AU - Dick, Danielle M.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Objective: The gene GRM8, a metabotropic glutamate receptor, has emerged as a gene of interest for its possible role in the development of alcohol dependence, with evidence of association with an electrophysiological endophenotype and level of response to alcohol as well as suggestive evidence of association with alcohol dependence. Method: The present study further investigated the association between GRM8 and alcohol dependence symptom counts among young adults using a new sample of individuals collected as part of the prospective sample (ages 18–26 years; N = 842) from the Collaborative Study on the Genetics of Alcoholism (COGA). Results: Two single-nucleotide polymorphisms were significantly associated with alcohol dependence in European Americans using the Nyholt corrected p value of .007: rs886003 (β = -.212, p = .0002) and rs17862325 (β = -.234, p < .0001), but not in African Americans, likely because of the lower power to detect association in this group. Conclusions: These results further implicate the role of glutamate receptor genes such as GRM8 in the development of alcohol dependence.

AB - Objective: The gene GRM8, a metabotropic glutamate receptor, has emerged as a gene of interest for its possible role in the development of alcohol dependence, with evidence of association with an electrophysiological endophenotype and level of response to alcohol as well as suggestive evidence of association with alcohol dependence. Method: The present study further investigated the association between GRM8 and alcohol dependence symptom counts among young adults using a new sample of individuals collected as part of the prospective sample (ages 18–26 years; N = 842) from the Collaborative Study on the Genetics of Alcoholism (COGA). Results: Two single-nucleotide polymorphisms were significantly associated with alcohol dependence in European Americans using the Nyholt corrected p value of .007: rs886003 (β = -.212, p = .0002) and rs17862325 (β = -.234, p < .0001), but not in African Americans, likely because of the lower power to detect association in this group. Conclusions: These results further implicate the role of glutamate receptor genes such as GRM8 in the development of alcohol dependence.

UR - http://www.scopus.com/inward/record.url?scp=84929427907&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929427907&partnerID=8YFLogxK

M3 - Article

C2 - 25978827

AN - SCOPUS:84929427907

VL - 76

SP - 414

EP - 418

JO - Journal of Studies on Alcohol and Drugs

JF - Journal of Studies on Alcohol and Drugs

SN - 1937-1888

IS - 3

ER -