Further mapping of an ataxia-telangiectasia locus to the chromosome 11q23 region

O. Sanal, S. Wei, T. Foroud, U. Malhotra, P. Concannon, P. Charmley, W. Salser, K. Lange, R. A. Gatti

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Abstract

We recently mapped the gene for ataxia-telangiectasia group A (ATA) to chromosome 11q22-23 by linkage analysis, using the genetic markers THY1 and pYNB3.12 (D11S144). The most likely order was cent-AT-S144-THY1. The present paper describes further mapping of the AT locus by means of a panel of 10 markers that span approximately 60 cM in the 11q22-23 region centered around S144 and THY1. Location scores indicate that three contiguous subsegments within the [S144-THY1] segment, as well as three contiguous segments telomeric to THY1, are each unlikely to contain the AT locus, while the more centromeric [STMY-S144] segment is most likely to contain the AT locus. These data, together with recent refinements in the linkage and physical maps of 11q22-23, place the AT locus at 11q23.

Original languageEnglish (US)
Pages (from-to)860-866
Number of pages7
JournalAmerican Journal of Human Genetics
Volume47
Issue number5
StatePublished - Nov 21 1990

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ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Sanal, O., Wei, S., Foroud, T., Malhotra, U., Concannon, P., Charmley, P., Salser, W., Lange, K., & Gatti, R. A. (1990). Further mapping of an ataxia-telangiectasia locus to the chromosome 11q23 region. American Journal of Human Genetics, 47(5), 860-866.