Further mapping of an ataxia-telangiectasia locus to the chromosome IIq23 region

O. Sanal, S. Wei, Tatiana Foroud, U. Malhotra, P. Concannon, P. Charmley, W. Salser, K. Lange, R. A. Gatti

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

We recently mapped the gene for ataxia-telangiectasia group A (ATA) to chromosome 11q22-23 by linkage analysis, using the genetic markers THY1 and pYNB3.12 (D11S144). The most likely order was cent-AT-S144-THY1. The present paper describes further mapping of the AT locus by means of a panel of 10 markers that span approximately 60 cM in the 11q22-23 region centered around S144 and THY1. Location scores indicate that three contiguous subsegments within the [S144-THY1] segment, as well as three contiguous segments telomeric to THY1, are each unlikely to contain the AT locus, while the more centromeric [STMY-S144] segment is most likely to contain the AT locus. These data, together with recent refinements in the linkage and physical maps of 11q22-23, place the AT locus at 11q23.

Original languageEnglish (US)
Pages (from-to)860-866
Number of pages7
JournalAmerican Journal of Human Genetics
Volume47
Issue number5
StatePublished - Nov 1990
Externally publishedYes

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Chromosomes, Human, 1-3
Ataxia Telangiectasia
Genetic Markers
Chromosomes
Genes
sorbitan monostearate

ASJC Scopus subject areas

  • Genetics

Cite this

Sanal, O., Wei, S., Foroud, T., Malhotra, U., Concannon, P., Charmley, P., ... Gatti, R. A. (1990). Further mapping of an ataxia-telangiectasia locus to the chromosome IIq23 region. American Journal of Human Genetics, 47(5), 860-866.

Further mapping of an ataxia-telangiectasia locus to the chromosome IIq23 region. / Sanal, O.; Wei, S.; Foroud, Tatiana; Malhotra, U.; Concannon, P.; Charmley, P.; Salser, W.; Lange, K.; Gatti, R. A.

In: American Journal of Human Genetics, Vol. 47, No. 5, 11.1990, p. 860-866.

Research output: Contribution to journalArticle

Sanal, O, Wei, S, Foroud, T, Malhotra, U, Concannon, P, Charmley, P, Salser, W, Lange, K & Gatti, RA 1990, 'Further mapping of an ataxia-telangiectasia locus to the chromosome IIq23 region', American Journal of Human Genetics, vol. 47, no. 5, pp. 860-866.
Sanal O, Wei S, Foroud T, Malhotra U, Concannon P, Charmley P et al. Further mapping of an ataxia-telangiectasia locus to the chromosome IIq23 region. American Journal of Human Genetics. 1990 Nov;47(5):860-866.
Sanal, O. ; Wei, S. ; Foroud, Tatiana ; Malhotra, U. ; Concannon, P. ; Charmley, P. ; Salser, W. ; Lange, K. ; Gatti, R. A. / Further mapping of an ataxia-telangiectasia locus to the chromosome IIq23 region. In: American Journal of Human Genetics. 1990 ; Vol. 47, No. 5. pp. 860-866.
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