This chapter helps learn the intricacies of efficient, accurate DNA damage response and repair enables researchers to create new anticancer agents that capitalize on cancer-specific alterations to those repair mechanisms, which are often early events in tumorigenic transformation. Many intrinsic and extrinsic factors threaten genome stability; and, when it is disrupted, a path of uncontrolled growth and cancer begins. Disruptions in DNA repair pathways predispose cells to accumulating damage, and subsequently, mutations. However, both mutations and heterozygous polymorphisms can alter DNA damage response and repair processes. Abundant evidence exists that, as cancers progress, they become increasingly more malignant by accumulating more mutations in their DNA repair proteins, which may limit or extinguish the functionality of a repair pathway or other key element of DNA maintenance.
|Original language||English (US)|
|Title of host publication||DNA Repair in Cancer Therapy|
|Number of pages||10|
|State||Published - Dec 1 2012|
ASJC Scopus subject areas