G2019S mutation in the leucine-rich repeat kinase 2 gene is not associated with multiple system atrophy

Laurie J. Ozelius, Tatiana Foroud, Susanne May, Geetha Senthil, Paola Sandroni, Phillip A. Low, Stephen Reich, Amy Colcher, Matthew B. Stern, William G. Ondo, Joseph Jankovic, Neng Huang, Caroline M. Tanner, Peter Novak, Sid Gilman, Frederick J. Marshall, G. Frederick Wooten, Thomas C. Chelimsky, Clifford W. Shults, Eliezer MasliahWalter Kukull, Virginia Lee, John Trojanowski, Ira Shoulson, Laurie Ozelius

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Multiple system atrophy (MSA) is characterized clinically by Parkinsonism, cerebellar dysfunction, and autonomic impairment. Multiple mutations in the LRRK2 gene are associated with parkinsonian disorders, and the most common one, the G2019S mutation, has been found in ∼1% of sporadic cases of Parkinsonism. In a well-characterized cohort of 136 subjects with probable MSA and 110 neurologically evaluated control subjects, none carried the G2019S mutation. We conclude that the G2019S mutation in the LRRK2 gene is unlikely to be associated with MSA.

Original languageEnglish
Pages (from-to)546-549
Number of pages4
JournalMovement Disorders
Volume22
Issue number4
DOIs
StatePublished - Mar 15 2007

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Multiple System Atrophy
Leucine
Parkinsonian Disorders
Phosphotransferases
Mutation
Genes
Cerebellar Diseases

Keywords

  • LRRK2
  • Multiple system atrophy
  • Parkinsonism

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

G2019S mutation in the leucine-rich repeat kinase 2 gene is not associated with multiple system atrophy. / Ozelius, Laurie J.; Foroud, Tatiana; May, Susanne; Senthil, Geetha; Sandroni, Paola; Low, Phillip A.; Reich, Stephen; Colcher, Amy; Stern, Matthew B.; Ondo, William G.; Jankovic, Joseph; Huang, Neng; Tanner, Caroline M.; Novak, Peter; Gilman, Sid; Marshall, Frederick J.; Wooten, G. Frederick; Chelimsky, Thomas C.; Shults, Clifford W.; Masliah, Eliezer; Kukull, Walter; Lee, Virginia; Trojanowski, John; Shoulson, Ira; Ozelius, Laurie.

In: Movement Disorders, Vol. 22, No. 4, 15.03.2007, p. 546-549.

Research output: Contribution to journalArticle

Ozelius, LJ, Foroud, T, May, S, Senthil, G, Sandroni, P, Low, PA, Reich, S, Colcher, A, Stern, MB, Ondo, WG, Jankovic, J, Huang, N, Tanner, CM, Novak, P, Gilman, S, Marshall, FJ, Wooten, GF, Chelimsky, TC, Shults, CW, Masliah, E, Kukull, W, Lee, V, Trojanowski, J, Shoulson, I & Ozelius, L 2007, 'G2019S mutation in the leucine-rich repeat kinase 2 gene is not associated with multiple system atrophy', Movement Disorders, vol. 22, no. 4, pp. 546-549. https://doi.org/10.1002/mds.21343
Ozelius, Laurie J. ; Foroud, Tatiana ; May, Susanne ; Senthil, Geetha ; Sandroni, Paola ; Low, Phillip A. ; Reich, Stephen ; Colcher, Amy ; Stern, Matthew B. ; Ondo, William G. ; Jankovic, Joseph ; Huang, Neng ; Tanner, Caroline M. ; Novak, Peter ; Gilman, Sid ; Marshall, Frederick J. ; Wooten, G. Frederick ; Chelimsky, Thomas C. ; Shults, Clifford W. ; Masliah, Eliezer ; Kukull, Walter ; Lee, Virginia ; Trojanowski, John ; Shoulson, Ira ; Ozelius, Laurie. / G2019S mutation in the leucine-rich repeat kinase 2 gene is not associated with multiple system atrophy. In: Movement Disorders. 2007 ; Vol. 22, No. 4. pp. 546-549.
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