GABA in morphine analgesia and tolerance

Subbiah Sivam, I. K. Ho

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Drugs affecting various steps of GABA transmission exhibit analgesia in a variety of experimental models in animals; this analgesic response generally requires high doses of the drugs and does not appear to be opiate-like since the GABAergic analgesia is naloxone-insensitive and lacks dependence liability. The outcome of the analgesia response is variable when opiate and GABAergic drugs are administered together; however, directly acting GABA receptor stimulants and GABA-transaminase inhibitors generally enhance the analgesic effect of opiates. The development of newer GABAergic drugs with greater potency and specificity may offer an alternative to opiate analgesics. The results obtained over the years, on the possible involvement of the GABA system in morphine tolerance and dependence are equivocal. Studies on region-specific changes in opiate-GABA interaction as well as opiate-GABA-benzodiazepine interaction are needed to further elucidate the role of GABA on opiate system.

Original languageEnglish (US)
Pages (from-to)199-208
Number of pages10
JournalLife Sciences
Volume37
Issue number3
DOIs
StatePublished - Jul 22 1985
Externally publishedYes

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Opiate Alkaloids
Analgesia
gamma-Aminobutyric Acid
Morphine
Analgesics
Pharmaceutical Preparations
4-Aminobutyrate Transaminase
Morphine Dependence
GABA Receptors
Naloxone
Benzodiazepines
Animals
Animal Models

ASJC Scopus subject areas

  • Pharmacology

Cite this

GABA in morphine analgesia and tolerance. / Sivam, Subbiah; Ho, I. K.

In: Life Sciences, Vol. 37, No. 3, 22.07.1985, p. 199-208.

Research output: Contribution to journalArticle

Sivam, Subbiah ; Ho, I. K. / GABA in morphine analgesia and tolerance. In: Life Sciences. 1985 ; Vol. 37, No. 3. pp. 199-208.
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