Galectin-3 and incident cognitive impairment in REGARDS, a cohort of blacks and whites

Anand Venkatraman, Peter Callas, Leslie A. McClure, Fred Unverzagt, Garima Arora, Virginia Howard, Virginia G. Wadley, Mary Cushman, Pankaj Arora

Research output: Contribution to journalArticle

3 Scopus citations


Introduction: The relationship between serum galectin-3 and incident cognitive impairment was analyzed in the Reasons for Geographic and Racial Differences in Stroke study. Methods: Baseline galectin-3 was measured in 455 cases of incident cognitive impairment and 546 controls. Galectin-3 was divided into quartiles based on the weighted distribution in the control group, and the first quartile was the referent. Results: There was an increasing odds of cognitive impairment across quartiles of galectin-3 (odds ratios, 1.00 [0.68–1.46], 1.45 [1.01–2.10], and 1.58 [1.10–2.27] relative to the quartile 1; P trend =.003) in an unadjusted model, which persisted after adjusting for age, sex, and race (P =.004). Adjustment for cardiovascular risk factors greatly attenuated this association (odds ratios, 0.97 [0.60–1.57], 1.52 [0.94–2.46], and 1.27 [0.76–2.12]; P =.15). The association differed by diabetes status (P interaction,.007). Among nondiabetics (293 cases, 411 controls), those with galectin-3 in the fourth compared with first quartile had an odds ratio of 1.6 (0.95–2.99; P trend,.02). In diabetics, the odds ratio was 0.23 (0.04–1.33). Discussion: Serum galectin-3 was associated with increased risk of incident cognitive impairment in a large cohort study of blacks and whites but only in nondiabetics.

Original languageEnglish (US)
Pages (from-to)165-172
Number of pages8
JournalAlzheimer's and Dementia: Translational Research and Clinical Interventions
StatePublished - 2018


  • Biomarkers
  • Cognitive impairment
  • Epidemiology
  • Galectin-3
  • Incidence
  • Risk factors

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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