Gallbladder ejection fraction and its relationship to sphincter of Oddi dysfunction

Thomas A. Ruffolo, Stuart Sherman, Glen A. Lehman, Robert H. Hawes

Research output: Contribution to journalArticle

46 Scopus citations


Theoretically, relative distal common bile duct obstruction due to sphincter of Oddi dysfunction may be a cause of poor gallbladder evacuation observed on quantitative cholescintigraphy. In this study, the relationship of sphincter of Oddi dysfunction to the gallbladder ejection fraction by quantitative cholescintigraphy was explored. Eighty-one patients with biliary-type pain and otherwise normal evaluations underwent quantitative cholescintigraphy, sphincter of Oddi manometry, and ERCP. Abnormalities of stimulated quantitative cholescintigraphy and/or sphincter of Oddi manometry were present in 70% of this study group. Manometric evidence of sphincter dysfunction was present in patients with similar frequency irrespective of the degree of gallbladder evacuation. In conclusion, abnormalities of quantitative cholescintigraphy and sphincter manometry appear to be independent factors, although frequent findings in this patient population.

Original languageEnglish (US)
Pages (from-to)289-292
Number of pages4
JournalDigestive diseases and sciences
Issue number2
StatePublished - Feb 1 1994


  • gallbladder ejection fraction
  • quantitative cholescintigraphy
  • sphincter of Oddi dysfunction

ASJC Scopus subject areas

  • Gastroenterology

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