Gallium-68 1,1,1-tris(5-methoxysalicylaldiminomethyl)ethane: A potential tracer for evaluation of regional myocardial blood flow

Mark Green, M. J. Welch, C. J. Mathias, K. A. Fox, R. M. Knabb, J. C. Huffman

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Reaction of tris(acetylacetonato)gallium(III) with 1,1,1-tris(5-methoxysalicylaldiminomethyl)ethane, H3[(5-MeOsal)3TAME], affords a neutral six-coordinate complex, Ga[(5-MeOsal)3TAME], for which the x-ray crystal structure is reported. The 67Ga and 68Ga complexes of H3[(5-MeOsal)3TAME] and the bis(salicylaldimine) of triethylenetetramine were prepared and characterized by paper chromatography and electrophoresis. The biodistribution of lipophilic 68Ga[(5-MeOsal)3TAME] was determined following intravenous injection in rats. Myocardial images obtained by positron emission tomography from three dogs injected with 68Ga[(5-MeOsal)3TAME] show a correlation between 68Ga uptake and regional myocardial blood flow. Single-pass coronary extraction studies in open-chest dogs indicate that 68Ga[(5-MeOsal)3TAME] behaves neither as a freely diffusible tracer nor as a microsphere analog.

Original languageEnglish (US)
Pages (from-to)170-180
Number of pages11
JournalJournal of Nuclear Medicine
Volume26
Issue number2
StatePublished - 1985
Externally publishedYes

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Ethane
Regional Blood Flow
Dogs
Trientine
Paper Electrophoresis
Paper Chromatography
Gallium
Microspheres
Intravenous Injections
Positron-Emission Tomography
Thorax
X-Rays
1,1,1-tris(5-methoxysalicylaldiminomethyl)ethane

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Gallium-68 1,1,1-tris(5-methoxysalicylaldiminomethyl)ethane : A potential tracer for evaluation of regional myocardial blood flow. / Green, Mark; Welch, M. J.; Mathias, C. J.; Fox, K. A.; Knabb, R. M.; Huffman, J. C.

In: Journal of Nuclear Medicine, Vol. 26, No. 2, 1985, p. 170-180.

Research output: Contribution to journalArticle

Green, Mark ; Welch, M. J. ; Mathias, C. J. ; Fox, K. A. ; Knabb, R. M. ; Huffman, J. C. / Gallium-68 1,1,1-tris(5-methoxysalicylaldiminomethyl)ethane : A potential tracer for evaluation of regional myocardial blood flow. In: Journal of Nuclear Medicine. 1985 ; Vol. 26, No. 2. pp. 170-180.
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AU - Fox, K. A.

AU - Knabb, R. M.

AU - Huffman, J. C.

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