Gallium-68 1,1,1-tris(5-methoxysalicylaldiminomethyl)ethane: A potential tracer for evaluation of regional myocardial blood flow

M. A. Green, M. J. Welch, C. J. Mathias, K. A. Fox, R. M. Knabb, J. C. Huffman

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

Reaction of tris(acetylacetonato)gallium(III) with 1,1,1-tris(5-methoxysalicylaldiminomethyl)ethane, H3[(5-MeOsal)3TAME], affords a neutral six-coordinate complex, Ga[(5-MeOsal)3TAME], for which the x-ray crystal structure is reported. The 67Ga and 68Ga complexes of H3[(5-MeOsal)3TAME] and the bis(salicylaldimine) of triethylenetetramine were prepared and characterized by paper chromatography and electrophoresis. The biodistribution of lipophilic 68Ga[(5-MeOsal)3TAME] was determined following intravenous injection in rats. Myocardial images obtained by positron emission tomography from three dogs injected with 68Ga[(5-MeOsal)3TAME] show a correlation between 68Ga uptake and regional myocardial blood flow. Single-pass coronary extraction studies in open-chest dogs indicate that 68Ga[(5-MeOsal)3TAME] behaves neither as a freely diffusible tracer nor as a microsphere analog.

Original languageEnglish (US)
Pages (from-to)170-180
Number of pages11
JournalJournal of Nuclear Medicine
Volume26
Issue number2
StatePublished - 1985

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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