Gamma oscillation in schizophrenia

Yong Wook Shin, Brian F. O'Donnell, Soyoung Youn, Jun Soo Kwon

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

Dysfunctional neural circuitry has been found to be involved in abnormalities of perception and cognition in patients with schizophrenia. Gamma oscillations are essential for integrating information within neural circuits and have therefore been associated with many perceptual and cognitive processes in healthy human subjects and animals. This review presents an overview of the neural basis of gamma oscillations and the abnormalities in the GABAergic interneuronal system thought to be responsible for gamma-range deficits in schizophrenia. We also review studies of gamma activity in sensory and cognitive processes, including auditory steady state response, attention, object representation, and working memory, in animals, healthy humans and patients with schizophrenia.

Original languageEnglish (US)
Pages (from-to)288-296
Number of pages9
JournalPsychiatry Investigation
Volume8
Issue number4
DOIs
StatePublished - Dec 1 2011

Keywords

  • GABAergic interneurons
  • Gamma oscillations
  • Schizophrenia
  • Steady state response

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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