Gastric electrical stimulation with Enterra therapy improves symptoms of idiopathic gastroparesis

R. W. Mccallum, I. Sarosiek, H. P. Parkman, W. Snape, F. Brody, John Wo, Thomas Nowak

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background: Gastric electrical stimulation (GES) is a therapeutic option for intractable symptoms of gastroparesis (GP). Idiopathic GP (ID-GP) represents a subset of GP. AIMS: A prospective, multicenter, double-blinded, randomized, crossover study to evaluate the safety and efficacy of Enterra GES in the treatment of chronic vomiting in ID-GP. Methods: Thirty-two ID-GP subjects (mean age 39; 81% F, mean 7.7 years of GP) were implanted with GES. The stimulator was turned ON for 11/2 months followed by double-blind randomization to consecutive 3-month crossover periods with the device either ON or OFF. ON stimulation was followed in unblinded fashion for another 4.5 months. Twenty-five subjects completed the crossover phase and 21 finished 1 year of follow-up. Key Results: During the unblinded ON period, there was a reduction in weekly vomiting frequency (WVF) from baseline (61.2%, P  0.10). Seventy-five percent of patients preferred the ON vs OFF period (P = 0.021). At 1 year, WVF remained decreased (median reduction = 87%, P 

Original languageEnglish (US)
JournalNeurogastroenterology and Motility
Volume25
Issue number10
DOIs
StatePublished - Oct 2013

Fingerprint

Gastroparesis
Electric Stimulation
Stomach
Vomiting
Therapeutics
Random Allocation
Cross-Over Studies
Safety
Equipment and Supplies

Keywords

  • Gastric stimulation
  • Gastroparesis
  • Idiopathic gastroparesis
  • Nausea
  • Vomiting

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Gastroenterology
  • Physiology

Cite this

Gastric electrical stimulation with Enterra therapy improves symptoms of idiopathic gastroparesis. / Mccallum, R. W.; Sarosiek, I.; Parkman, H. P.; Snape, W.; Brody, F.; Wo, John; Nowak, Thomas.

In: Neurogastroenterology and Motility, Vol. 25, No. 10, 10.2013.

Research output: Contribution to journalArticle

Mccallum, R. W. ; Sarosiek, I. ; Parkman, H. P. ; Snape, W. ; Brody, F. ; Wo, John ; Nowak, Thomas. / Gastric electrical stimulation with Enterra therapy improves symptoms of idiopathic gastroparesis. In: Neurogastroenterology and Motility. 2013 ; Vol. 25, No. 10.
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