Gastrinoma excision for cure: A prospective analysis

Thomas Howard, Michael J. Zinner, Bruce E. Stabile, Edward Passaro

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

The role of surgery in the treatment of gastrinoma is unclear. The purpose of this study was to determine prospectively the surgical cure rate using a controlled clinical trial. Eleven patients who fit the entry criteria underwent abdominal exploration and attempted tumor resection for cure. A historical control group was used for comparison. Cure was defined as: (1) normal serum gastrin level, (2) no response to intravenous secretin, (3) no symptoms when antisecretory medications are stopped, and (4) no tumor recurrence on follow-up examination. Tumors found in both groups tended to be small (1.5 cm vs. 2.2 cm), multiple (71% vs. 40%), and in lymph nodes (70% vs. 70%). All tumors identified were located anatomically within the gastrinoma triangle. Tumors were found in 10 of 11 patients (91%) in the study group, and significantly more patients had their tumors excised for cure as compared to controls (82% vs. 27%, p <0.05). The current prospective cure rate for gastrinoma is higher than previously appreciated and tumors within lymph nodes do not preclude curative resection.

Original languageEnglish (US)
Pages (from-to)9-14
Number of pages6
JournalAnnals of Surgery
Volume211
Issue number1
StatePublished - 1990
Externally publishedYes

Fingerprint

Gastrinoma
Neoplasms
Lymph Nodes
Secretin
Gastrins
Controlled Clinical Trials
Recurrence
Control Groups
Serum

ASJC Scopus subject areas

  • Surgery

Cite this

Howard, T., Zinner, M. J., Stabile, B. E., & Passaro, E. (1990). Gastrinoma excision for cure: A prospective analysis. Annals of Surgery, 211(1), 9-14.

Gastrinoma excision for cure : A prospective analysis. / Howard, Thomas; Zinner, Michael J.; Stabile, Bruce E.; Passaro, Edward.

In: Annals of Surgery, Vol. 211, No. 1, 1990, p. 9-14.

Research output: Contribution to journalArticle

Howard, T, Zinner, MJ, Stabile, BE & Passaro, E 1990, 'Gastrinoma excision for cure: A prospective analysis', Annals of Surgery, vol. 211, no. 1, pp. 9-14.
Howard T, Zinner MJ, Stabile BE, Passaro E. Gastrinoma excision for cure: A prospective analysis. Annals of Surgery. 1990;211(1):9-14.
Howard, Thomas ; Zinner, Michael J. ; Stabile, Bruce E. ; Passaro, Edward. / Gastrinoma excision for cure : A prospective analysis. In: Annals of Surgery. 1990 ; Vol. 211, No. 1. pp. 9-14.
@article{8fbae4f68b284dab9a4572edf733b319,
title = "Gastrinoma excision for cure: A prospective analysis",
abstract = "The role of surgery in the treatment of gastrinoma is unclear. The purpose of this study was to determine prospectively the surgical cure rate using a controlled clinical trial. Eleven patients who fit the entry criteria underwent abdominal exploration and attempted tumor resection for cure. A historical control group was used for comparison. Cure was defined as: (1) normal serum gastrin level, (2) no response to intravenous secretin, (3) no symptoms when antisecretory medications are stopped, and (4) no tumor recurrence on follow-up examination. Tumors found in both groups tended to be small (1.5 cm vs. 2.2 cm), multiple (71{\%} vs. 40{\%}), and in lymph nodes (70{\%} vs. 70{\%}). All tumors identified were located anatomically within the gastrinoma triangle. Tumors were found in 10 of 11 patients (91{\%}) in the study group, and significantly more patients had their tumors excised for cure as compared to controls (82{\%} vs. 27{\%}, p <0.05). The current prospective cure rate for gastrinoma is higher than previously appreciated and tumors within lymph nodes do not preclude curative resection.",
author = "Thomas Howard and Zinner, {Michael J.} and Stabile, {Bruce E.} and Edward Passaro",
year = "1990",
language = "English (US)",
volume = "211",
pages = "9--14",
journal = "Annals of Surgery",
issn = "0003-4932",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Gastrinoma excision for cure

T2 - A prospective analysis

AU - Howard, Thomas

AU - Zinner, Michael J.

AU - Stabile, Bruce E.

AU - Passaro, Edward

PY - 1990

Y1 - 1990

N2 - The role of surgery in the treatment of gastrinoma is unclear. The purpose of this study was to determine prospectively the surgical cure rate using a controlled clinical trial. Eleven patients who fit the entry criteria underwent abdominal exploration and attempted tumor resection for cure. A historical control group was used for comparison. Cure was defined as: (1) normal serum gastrin level, (2) no response to intravenous secretin, (3) no symptoms when antisecretory medications are stopped, and (4) no tumor recurrence on follow-up examination. Tumors found in both groups tended to be small (1.5 cm vs. 2.2 cm), multiple (71% vs. 40%), and in lymph nodes (70% vs. 70%). All tumors identified were located anatomically within the gastrinoma triangle. Tumors were found in 10 of 11 patients (91%) in the study group, and significantly more patients had their tumors excised for cure as compared to controls (82% vs. 27%, p <0.05). The current prospective cure rate for gastrinoma is higher than previously appreciated and tumors within lymph nodes do not preclude curative resection.

AB - The role of surgery in the treatment of gastrinoma is unclear. The purpose of this study was to determine prospectively the surgical cure rate using a controlled clinical trial. Eleven patients who fit the entry criteria underwent abdominal exploration and attempted tumor resection for cure. A historical control group was used for comparison. Cure was defined as: (1) normal serum gastrin level, (2) no response to intravenous secretin, (3) no symptoms when antisecretory medications are stopped, and (4) no tumor recurrence on follow-up examination. Tumors found in both groups tended to be small (1.5 cm vs. 2.2 cm), multiple (71% vs. 40%), and in lymph nodes (70% vs. 70%). All tumors identified were located anatomically within the gastrinoma triangle. Tumors were found in 10 of 11 patients (91%) in the study group, and significantly more patients had their tumors excised for cure as compared to controls (82% vs. 27%, p <0.05). The current prospective cure rate for gastrinoma is higher than previously appreciated and tumors within lymph nodes do not preclude curative resection.

UR - http://www.scopus.com/inward/record.url?scp=0025058022&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025058022&partnerID=8YFLogxK

M3 - Article

C2 - 2294850

AN - SCOPUS:0025058022

VL - 211

SP - 9

EP - 14

JO - Annals of Surgery

JF - Annals of Surgery

SN - 0003-4932

IS - 1

ER -