Gastroesophageal reflux in infants and children-comparative accuracy of diagnostic methods

Thiru S. Arasu, Robert Wyllie, Joseph F. Fitzgerald, Edmund A. Franken, Aslam R. Siddiqui, Glen A. Lehman, Howard Eigen, Jay L. Grosfeld

Research output: Contribution to journalArticle

121 Scopus citations


To assess the diagnostic accuracy of methods employed for detection of gastroesophageal reflux, 30 infants and children with symptoms of GER were evaluated by upper gastrointestinal series, gastroesophageal scintiscan, measurement of mean resting lower esophageal sphincter pressure, esophageal intraluminal pH measurement (acid reflux test), and endoscopy. Fifteen control patients were also evaluated by the above studies. GER was demonstrated by UGI in 15 and by GE scintiscan in 17 study patients. LESP less than 15 mm Hg was noted in 12 and a positive acid reflux test was obtained in 29 study patients. Esophagitis was detected in two (of 30) study patients radiographically and in 15 (of 21) study patients by upper gastrointestinal endoscopy. Pulmonary aspiration of gastric contents was not detected by the radionuclide method. None of the 15 control patients had GER demonstrated with any of the above methods. These studies indicate that (1) the acid reflux test correlates most closely with symptoms of GER; (2) the GE scintiscan is complementary to the UGI in the diagnosis of GER, i.e., the combination increases sensitivity; (3) normal LESP does not necessarily exclude GER; and (4) endoscopy is superior to the UGI in detecting the presence of esophagitis.

Original languageEnglish (US)
Pages (from-to)798-803
Number of pages6
JournalThe Journal of pediatrics
Issue number5
StatePublished - May 1980

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Gastroesophageal reflux in infants and children-comparative accuracy of diagnostic methods'. Together they form a unique fingerprint.

  • Cite this

    Arasu, T. S., Wyllie, R., Fitzgerald, J. F., Franken, E. A., Siddiqui, A. R., Lehman, G. A., Eigen, H., & Grosfeld, J. L. (1980). Gastroesophageal reflux in infants and children-comparative accuracy of diagnostic methods. The Journal of pediatrics, 96(5), 798-803.