GBR-12909-induced self-injurious behavior: role of dopamine

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

A regimen of repeated administration of GBR (10 or 20 mg/kg/day, i.p., for 4 days) to female Sprague-Dawley rats induced a dose-and time-related increase in the incidence of self-injurious behavior (SIB) that consisted of injury to body areas, paws and tail. The treatment regimen decreased striatal DA and DOPAC levels. Dopaminergic denervation with 6-hydroxydopamine (6-OHDA) or D1 DA antagonist, SCH-23390 or D2 DA antagonist, spiperone, blocked the GBR-induced SIB. Male rats were less sensitive than female rats to exhibit a comparable incidence of SIB. Taken together, the study reveals that repeated administration of GBR induces SIB that is dependent on the integrity of nigrostriatal dopaminergic system and the presence of D1 and/or D2 DA receptors.

Original languageEnglish (US)
Pages (from-to)259-263
Number of pages5
JournalBrain research
Volume690
Issue number2
DOIs
StatePublished - Sep 4 1995

Keywords

  • 6-Hydroxydopamine
  • D1 Receptor
  • D2 Receptor
  • Dopamine
  • GBR-12909
  • Self-injurious behavior
  • Striatum

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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