GCH1 haplotypes and cardiovascular risk in HIV

James E. Slaven, David W. Haas, Ziyue Liu, James H. Stein, Todd T. Brown, Samir Gupta

Research output: Contribution to journalArticle

Abstract

Heightened systemic inflammation contributes to cardiovascular (CVD) events in people living with HIV (PLWH), although not all PLWH develop CVD, thus suggesting a genetic modifying role. We examined GCH1 polymorphisms, which have been associated with reduced endothelial function in European populations with CVD and increased inflammation, in a racially diverse cohort of US PLWH initiating antiretroviral therapy (ART). GCH1 polymorphisms differed by race and were not associated with flow-mediated dilation or carotid intima-media thickness before or after 48 weeks of ART.

Original languageEnglish (US)
Pages (from-to)1669-1671
Number of pages3
JournalAIDS
Volume33
Issue number10
DOIs
StatePublished - Aug 1 2019

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Haplotypes
HIV
Inflammation
Carotid Intima-Media Thickness
Dilatation
Therapeutics
Population

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Slaven, J. E., Haas, D. W., Liu, Z., Stein, J. H., Brown, T. T., & Gupta, S. (2019). GCH1 haplotypes and cardiovascular risk in HIV. AIDS, 33(10), 1669-1671. https://doi.org/10.1097/QAD.0000000000002263

GCH1 haplotypes and cardiovascular risk in HIV. / Slaven, James E.; Haas, David W.; Liu, Ziyue; Stein, James H.; Brown, Todd T.; Gupta, Samir.

In: AIDS, Vol. 33, No. 10, 01.08.2019, p. 1669-1671.

Research output: Contribution to journalArticle

Slaven, JE, Haas, DW, Liu, Z, Stein, JH, Brown, TT & Gupta, S 2019, 'GCH1 haplotypes and cardiovascular risk in HIV', AIDS, vol. 33, no. 10, pp. 1669-1671. https://doi.org/10.1097/QAD.0000000000002263
Slaven, James E. ; Haas, David W. ; Liu, Ziyue ; Stein, James H. ; Brown, Todd T. ; Gupta, Samir. / GCH1 haplotypes and cardiovascular risk in HIV. In: AIDS. 2019 ; Vol. 33, No. 10. pp. 1669-1671.
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