Gd-enhanced MR imaging of acute and chronic experimental demyelinating lesions

M. A. Kuharik, M. K. Edwards, Martin Farlow, G. J. Becker, B. Azzarelli, E. C. Klatte, G. T. Augustyn, R. G. Dreesen

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Experimental allergic encephalomyelitis, a demyelinating disease with marked similarity to multiple sclerosis, was produced in two of 12 dogs. All dogs were studied with serial MR imaging. T1- and T2-weighted MR images were obtained both before and after IV Gd-DTPA. Multiple, new periventricular white matter demyelinating lesions were observed after each clinical episode of the disease. Like multiple sclerosis, the acute lesions of experimental allergic encephalomyelitis on T2-weighted MR images were indistinguishable from the older, more chronic lesions. However, after Gd-DTPA, there was bright paramagnetic enhancement of the acute lesions and, in one animal, no enhancement of the chronic lesions on T1-weighted MR images. At necropsy, the differences in the MR paramagnetic enhancement correlated well with the relative histologic age of the demyelinating lesions. Our results suggest that MR with Gd-DTPA may be used to differentite acute, active demyelinating lesions from the more chronic, inactive lesions in this animal model.

Original languageEnglish
Pages (from-to)643-648
Number of pages6
JournalAmerican Journal of Neuroradiology
Volume9
Issue number4
StatePublished - 1988

Fingerprint

Gadolinium DTPA
Autoimmune Experimental Encephalomyelitis
Multiple Sclerosis
Dogs
Demyelinating Diseases
Animal Models

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Kuharik, M. A., Edwards, M. K., Farlow, M., Becker, G. J., Azzarelli, B., Klatte, E. C., ... Dreesen, R. G. (1988). Gd-enhanced MR imaging of acute and chronic experimental demyelinating lesions. American Journal of Neuroradiology, 9(4), 643-648.

Gd-enhanced MR imaging of acute and chronic experimental demyelinating lesions. / Kuharik, M. A.; Edwards, M. K.; Farlow, Martin; Becker, G. J.; Azzarelli, B.; Klatte, E. C.; Augustyn, G. T.; Dreesen, R. G.

In: American Journal of Neuroradiology, Vol. 9, No. 4, 1988, p. 643-648.

Research output: Contribution to journalArticle

Kuharik, MA, Edwards, MK, Farlow, M, Becker, GJ, Azzarelli, B, Klatte, EC, Augustyn, GT & Dreesen, RG 1988, 'Gd-enhanced MR imaging of acute and chronic experimental demyelinating lesions', American Journal of Neuroradiology, vol. 9, no. 4, pp. 643-648.
Kuharik MA, Edwards MK, Farlow M, Becker GJ, Azzarelli B, Klatte EC et al. Gd-enhanced MR imaging of acute and chronic experimental demyelinating lesions. American Journal of Neuroradiology. 1988;9(4):643-648.
Kuharik, M. A. ; Edwards, M. K. ; Farlow, Martin ; Becker, G. J. ; Azzarelli, B. ; Klatte, E. C. ; Augustyn, G. T. ; Dreesen, R. G. / Gd-enhanced MR imaging of acute and chronic experimental demyelinating lesions. In: American Journal of Neuroradiology. 1988 ; Vol. 9, No. 4. pp. 643-648.
@article{c8416df4c4f84d83a89fbafbcaf8658d,
title = "Gd-enhanced MR imaging of acute and chronic experimental demyelinating lesions",
abstract = "Experimental allergic encephalomyelitis, a demyelinating disease with marked similarity to multiple sclerosis, was produced in two of 12 dogs. All dogs were studied with serial MR imaging. T1- and T2-weighted MR images were obtained both before and after IV Gd-DTPA. Multiple, new periventricular white matter demyelinating lesions were observed after each clinical episode of the disease. Like multiple sclerosis, the acute lesions of experimental allergic encephalomyelitis on T2-weighted MR images were indistinguishable from the older, more chronic lesions. However, after Gd-DTPA, there was bright paramagnetic enhancement of the acute lesions and, in one animal, no enhancement of the chronic lesions on T1-weighted MR images. At necropsy, the differences in the MR paramagnetic enhancement correlated well with the relative histologic age of the demyelinating lesions. Our results suggest that MR with Gd-DTPA may be used to differentite acute, active demyelinating lesions from the more chronic, inactive lesions in this animal model.",
author = "Kuharik, {M. A.} and Edwards, {M. K.} and Martin Farlow and Becker, {G. J.} and B. Azzarelli and Klatte, {E. C.} and Augustyn, {G. T.} and Dreesen, {R. G.}",
year = "1988",
language = "English",
volume = "9",
pages = "643--648",
journal = "American Journal of Neuroradiology",
issn = "0195-6108",
publisher = "American Society of Neuroradiology",
number = "4",

}

TY - JOUR

T1 - Gd-enhanced MR imaging of acute and chronic experimental demyelinating lesions

AU - Kuharik, M. A.

AU - Edwards, M. K.

AU - Farlow, Martin

AU - Becker, G. J.

AU - Azzarelli, B.

AU - Klatte, E. C.

AU - Augustyn, G. T.

AU - Dreesen, R. G.

PY - 1988

Y1 - 1988

N2 - Experimental allergic encephalomyelitis, a demyelinating disease with marked similarity to multiple sclerosis, was produced in two of 12 dogs. All dogs were studied with serial MR imaging. T1- and T2-weighted MR images were obtained both before and after IV Gd-DTPA. Multiple, new periventricular white matter demyelinating lesions were observed after each clinical episode of the disease. Like multiple sclerosis, the acute lesions of experimental allergic encephalomyelitis on T2-weighted MR images were indistinguishable from the older, more chronic lesions. However, after Gd-DTPA, there was bright paramagnetic enhancement of the acute lesions and, in one animal, no enhancement of the chronic lesions on T1-weighted MR images. At necropsy, the differences in the MR paramagnetic enhancement correlated well with the relative histologic age of the demyelinating lesions. Our results suggest that MR with Gd-DTPA may be used to differentite acute, active demyelinating lesions from the more chronic, inactive lesions in this animal model.

AB - Experimental allergic encephalomyelitis, a demyelinating disease with marked similarity to multiple sclerosis, was produced in two of 12 dogs. All dogs were studied with serial MR imaging. T1- and T2-weighted MR images were obtained both before and after IV Gd-DTPA. Multiple, new periventricular white matter demyelinating lesions were observed after each clinical episode of the disease. Like multiple sclerosis, the acute lesions of experimental allergic encephalomyelitis on T2-weighted MR images were indistinguishable from the older, more chronic lesions. However, after Gd-DTPA, there was bright paramagnetic enhancement of the acute lesions and, in one animal, no enhancement of the chronic lesions on T1-weighted MR images. At necropsy, the differences in the MR paramagnetic enhancement correlated well with the relative histologic age of the demyelinating lesions. Our results suggest that MR with Gd-DTPA may be used to differentite acute, active demyelinating lesions from the more chronic, inactive lesions in this animal model.

UR - http://www.scopus.com/inward/record.url?scp=0023719084&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023719084&partnerID=8YFLogxK

M3 - Article

VL - 9

SP - 643

EP - 648

JO - American Journal of Neuroradiology

JF - American Journal of Neuroradiology

SN - 0195-6108

IS - 4

ER -