Gd-enhanced MR imaging of acute and chronic experimental demyelinating lesions

M. A. Kuharik, M. K. Edwards, M. R. Farlow, G. J. Becker, B. Azzarelli, E. C. Klatte, G. T. Augustyn, R. G. Dreesen

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31 Scopus citations


Experimental allergic encephalomyelitis, a demyelinating disease with marked similarity to multiple sclerosis, was produced in two of 12 dogs. All dogs were studied with serial MR imaging. T1- and T2-weighted MR images were obtained both before and after IV Gd-DTPA. Multiple, new periventricular white matter demyelinating lesions were observed after each clinical episode of the disease. Like multiple sclerosis, the acute lesions of experimental allergic encephalomyelitis on T2-weighted MR images were indistinguishable from the older, more chronic lesions. However, after Gd-DTPA, there was bright paramagnetic enhancement of the acute lesions and, in one animal, no enhancement of the chronic lesions on T1-weighted MR images. At necropsy, the differences in the MR paramagnetic enhancement correlated well with the relative histologic age of the demyelinating lesions. Our results suggest that MR with Gd-DTPA may be used to differentite acute, active demyelinating lesions from the more chronic, inactive lesions in this animal model.

Original languageEnglish (US)
Pages (from-to)643-648
Number of pages6
JournalAmerican Journal of Neuroradiology
Issue number4
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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    Kuharik, M. A., Edwards, M. K., Farlow, M. R., Becker, G. J., Azzarelli, B., Klatte, E. C., Augustyn, G. T., & Dreesen, R. G. (1988). Gd-enhanced MR imaging of acute and chronic experimental demyelinating lesions. American Journal of Neuroradiology, 9(4), 643-648.