Gender differences in serum leptin levels in humans

Matthew S. Hickey, Richard G. Israel, Suzanne N. Gardiner, Robert Considine, Michael R. McCammon, Gilian L. Tyndall, Joseph A. Houmard, Richard H L Marks, Jose F. Caro

Research output: Contribution to journalArticle

182 Citations (Scopus)

Abstract

Leptin, the product of the ob gene, is an adipose tissue-derived hormone that appears to regulate both satiety and thermogenesis. In the present report, we have reexamined the relationship between circulating leptin concentration and body fat in humans using a more valid measure of adiposity (hydrodensitometry) and have extended these observations to examine the influence of regional body fat distribution and cardiorespiratory fitness. Fasting serum leptin concentration was 6.9 ± 0.3 ng · ml-1 in males (N = 333) and 15.2 ± 1.3 ng · ml-1 in females (N = 63). Interestingly, total fat mass did not differ between groups (males 20.5 ± 0.5 kg; females 20.4 ± 1.5 kg), suggesting that females have higher leptin levels per unit fat mass. In a multiple regression model, fat mass was the best predictor of serum leptin concentration in males, accounting for 51% of the variance in leptin concentration. In females, percentage body fat was the best predictor of leptin, accounting for 49% of the variance. In both groups, the relationship between leptin and adiposity remained significant after adjusting for age, maximal treadmill time, waist circumference, and fasting insulin concentration. These observations support previous conclusions that circulating leptin is primarily a function of adiposity and demonstrate for the first time that this relationship is independent of fat distribution or cardiorespiratory fitness. The data also suggest that there is a gender dichotomy in the relationship between leptin and body fat mass in humans.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalBiochemical and Molecular Medicine
Volume59
Issue number1
DOIs
StatePublished - Oct 1996
Externally publishedYes

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Leptin
Fats
Serum
Adipose Tissue
Adiposity
Fasting
Body Fat Distribution
Exercise equipment
Thermogenesis
Waist Circumference
Hormones
Insulin
Tissue

ASJC Scopus subject areas

  • Biochemistry

Cite this

Hickey, M. S., Israel, R. G., Gardiner, S. N., Considine, R., McCammon, M. R., Tyndall, G. L., ... Caro, J. F. (1996). Gender differences in serum leptin levels in humans. Biochemical and Molecular Medicine, 59(1), 1-6. https://doi.org/10.1006/bmme.1996.0056

Gender differences in serum leptin levels in humans. / Hickey, Matthew S.; Israel, Richard G.; Gardiner, Suzanne N.; Considine, Robert; McCammon, Michael R.; Tyndall, Gilian L.; Houmard, Joseph A.; Marks, Richard H L; Caro, Jose F.

In: Biochemical and Molecular Medicine, Vol. 59, No. 1, 10.1996, p. 1-6.

Research output: Contribution to journalArticle

Hickey, MS, Israel, RG, Gardiner, SN, Considine, R, McCammon, MR, Tyndall, GL, Houmard, JA, Marks, RHL & Caro, JF 1996, 'Gender differences in serum leptin levels in humans', Biochemical and Molecular Medicine, vol. 59, no. 1, pp. 1-6. https://doi.org/10.1006/bmme.1996.0056
Hickey, Matthew S. ; Israel, Richard G. ; Gardiner, Suzanne N. ; Considine, Robert ; McCammon, Michael R. ; Tyndall, Gilian L. ; Houmard, Joseph A. ; Marks, Richard H L ; Caro, Jose F. / Gender differences in serum leptin levels in humans. In: Biochemical and Molecular Medicine. 1996 ; Vol. 59, No. 1. pp. 1-6.
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