Gene × environment interaction by a longitudinal epigenome-wide association study (LEWAS) overcomes limitations of genome-wide association study (GWAS)

Debomoy Lahiri, Bryan Maloney

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The goal of genome-wide association studies is to identify SNPs unique to disease. It usually involves a single sampling from subjects lifetimes. While primary DNA sequence variation influences gene-expression levels, expression is also influenced by epigenetics, including the 'somatic epitype (GSE), an epigenotype acquired postnatally. While genes are inherited, and novel polymorphisms do not routinely appear, GSE is fluid. Furthermore, GSE could respond to environmental factors (such as heavy metals) and to differences in exercise, maternal care and dietary supplements - all of which postnatally modify oxidation or methylation of DNA, leading to altered gene expression. Change in epigenetic status may be critical for the development of many diseases. We propose a 'longitudinal epigenome-wide association study, wherein GSE are measured at multiple time points along with subjects histories. This Longitudinal epigenome-wide association study, based on the 'dynamic somatic epitype over the 'static genotype, merits further investigation.

Original languageEnglish
Pages (from-to)685-699
Number of pages15
JournalEpigenomics
Volume4
Issue number6
DOIs
StatePublished - Dec 2012

Fingerprint

Gene-Environment Interaction
Genome-Wide Association Study
Epigenomics
Gene Expression
DNA Methylation
Dietary Supplements
Heavy Metals
Single Nucleotide Polymorphism
Genotype
Mothers
Genes

Keywords

  • association study
  • environment
  • epigenetics
  • epigenomics
  • genomics
  • GWAS
  • LEWAS

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

Cite this

@article{a9b09dfeed3842edb8c9403d41170053,
title = "Gene × environment interaction by a longitudinal epigenome-wide association study (LEWAS) overcomes limitations of genome-wide association study (GWAS)",
abstract = "The goal of genome-wide association studies is to identify SNPs unique to disease. It usually involves a single sampling from subjects lifetimes. While primary DNA sequence variation influences gene-expression levels, expression is also influenced by epigenetics, including the 'somatic epitype (GSE), an epigenotype acquired postnatally. While genes are inherited, and novel polymorphisms do not routinely appear, GSE is fluid. Furthermore, GSE could respond to environmental factors (such as heavy metals) and to differences in exercise, maternal care and dietary supplements - all of which postnatally modify oxidation or methylation of DNA, leading to altered gene expression. Change in epigenetic status may be critical for the development of many diseases. We propose a 'longitudinal epigenome-wide association study, wherein GSE are measured at multiple time points along with subjects histories. This Longitudinal epigenome-wide association study, based on the 'dynamic somatic epitype over the 'static genotype, merits further investigation.",
keywords = "association study, environment, epigenetics, epigenomics, genomics, GWAS, LEWAS",
author = "Debomoy Lahiri and Bryan Maloney",
year = "2012",
month = "12",
doi = "10.2217/epi.12.60",
language = "English",
volume = "4",
pages = "685--699",
journal = "Epigenomics",
issn = "1750-1911",
publisher = "Future Medicine Ltd.",
number = "6",

}

TY - JOUR

T1 - Gene × environment interaction by a longitudinal epigenome-wide association study (LEWAS) overcomes limitations of genome-wide association study (GWAS)

AU - Lahiri, Debomoy

AU - Maloney, Bryan

PY - 2012/12

Y1 - 2012/12

N2 - The goal of genome-wide association studies is to identify SNPs unique to disease. It usually involves a single sampling from subjects lifetimes. While primary DNA sequence variation influences gene-expression levels, expression is also influenced by epigenetics, including the 'somatic epitype (GSE), an epigenotype acquired postnatally. While genes are inherited, and novel polymorphisms do not routinely appear, GSE is fluid. Furthermore, GSE could respond to environmental factors (such as heavy metals) and to differences in exercise, maternal care and dietary supplements - all of which postnatally modify oxidation or methylation of DNA, leading to altered gene expression. Change in epigenetic status may be critical for the development of many diseases. We propose a 'longitudinal epigenome-wide association study, wherein GSE are measured at multiple time points along with subjects histories. This Longitudinal epigenome-wide association study, based on the 'dynamic somatic epitype over the 'static genotype, merits further investigation.

AB - The goal of genome-wide association studies is to identify SNPs unique to disease. It usually involves a single sampling from subjects lifetimes. While primary DNA sequence variation influences gene-expression levels, expression is also influenced by epigenetics, including the 'somatic epitype (GSE), an epigenotype acquired postnatally. While genes are inherited, and novel polymorphisms do not routinely appear, GSE is fluid. Furthermore, GSE could respond to environmental factors (such as heavy metals) and to differences in exercise, maternal care and dietary supplements - all of which postnatally modify oxidation or methylation of DNA, leading to altered gene expression. Change in epigenetic status may be critical for the development of many diseases. We propose a 'longitudinal epigenome-wide association study, wherein GSE are measured at multiple time points along with subjects histories. This Longitudinal epigenome-wide association study, based on the 'dynamic somatic epitype over the 'static genotype, merits further investigation.

KW - association study

KW - environment

KW - epigenetics

KW - epigenomics

KW - genomics

KW - GWAS

KW - LEWAS

UR - http://www.scopus.com/inward/record.url?scp=84871454822&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871454822&partnerID=8YFLogxK

U2 - 10.2217/epi.12.60

DO - 10.2217/epi.12.60

M3 - Article

VL - 4

SP - 685

EP - 699

JO - Epigenomics

JF - Epigenomics

SN - 1750-1911

IS - 6

ER -