Gene expression in brain: A window on ethanol dependence, neuroadaptation, and preference

Paula L. Hoffman, Michael Miles, Howard J. Edenberg, Wolfgang Sommer, Boris Tabakoff, Jeanne M. Wehner, Joanne Lewohl

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Abstract

This article represents the proceedings of a symposium at the 2002 joint RSA/ISBRA Conference in San Francisco, California. The organizer was Paula L. Hoffman and the co-chairs were Paula L. Hoffman and Michael Miles. The presentations were (1) Introduction and overview of the use of DNA microarrays, by Michael Miles; (2) DNA microarray analysis of gene expression in brains of P and NP rats, by Howard J. Edenberg; (3) Gene expression patterns in brain regions of AA and ANA rats, by Wolfgang Sommer; (4) Patterns of gene expression in brains of selected lines of mice that differ in ethanol tolerance, by Boris Tabakoff; (5) Gene expression profiling related to initial sensitivity and tolerance in gamma-protein kinase C mutants, by Jeanne Wehner; and (6) Gene expression patterns in human alcoholic brain: from microarrays to protein profiles, by Joanne Lewohl.

Original languageEnglish (US)
Pages (from-to)155-168
Number of pages14
JournalAlcoholism: Clinical and Experimental Research
Volume27
Issue number2
DOIs
StatePublished - Feb 1 2003

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Keywords

  • Alcohol preference
  • Alcohol tolerance
  • Alcoholism
  • DNA microarrays
  • Gene expression
  • Null mutants
  • Selected lines
  • Transgenics

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

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