Gene expression profile of adult T-cell acute lymphocytic leukemia identifies distinct subsets of patients with different response to therapy and survival

Sabina Chiaretti, Xiaochun Li, Robert Gentleman, Antonella Vitale, Marco Vignetti, Franco Mandelli, Jerome Ritz, Robin Foa

Research output: Contribution to journalArticle

223 Citations (Scopus)

Abstract

Gene expression profiles were examined in 33 adult patients with T-cell acute lymphocytic leukemia (T-ALL). Nonspecific filtering criteria identified 313 genes differentially expressed in the leukemic cells. Hierarchical clustering of samples identified 2 groups that reflected the degree of T-cell differentiation but was not associated with clinical outcome. Comparison between refractory patients and those who responded to induction chemotherapy identified a single gene, interleukin 8 (IL-8), that was highly expressed in refractory T-ALL cells and a set of 30 genes that was highly expressed in leukemic cells from patients who achieved complete remission. We next identified 19 genes that were differentially expressed in T-ALL cells from patients who either had a relapse or remained in continuous complete remission. A model based on the expression of 3 of these genes was predictive of duration of remission. The 3-gene model was validated on a further set of T-ALL samples from 18 additional patients treated on the same clinical protocol. This study demonstrates that gene expression profiling can identify a limited number of genes that are predictive of response to induction therapy and remission duration in adult patients with T-ALL.

Original languageEnglish (US)
Pages (from-to)2771-2778
Number of pages8
JournalBlood
Volume103
Issue number7
DOIs
StatePublished - Apr 1 2004
Externally publishedYes

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Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
T-cells
Transcriptome
Gene expression
Genes
Survival
Refractory materials
Therapeutics
Remission Induction
Induction Chemotherapy
Gene Expression Profiling
Clinical Protocols
Chemotherapy
Interleukin-8
Cluster Analysis
Cell Differentiation
T-Lymphocytes
Gene Expression
Recurrence

ASJC Scopus subject areas

  • Hematology

Cite this

Gene expression profile of adult T-cell acute lymphocytic leukemia identifies distinct subsets of patients with different response to therapy and survival. / Chiaretti, Sabina; Li, Xiaochun; Gentleman, Robert; Vitale, Antonella; Vignetti, Marco; Mandelli, Franco; Ritz, Jerome; Foa, Robin.

In: Blood, Vol. 103, No. 7, 01.04.2004, p. 2771-2778.

Research output: Contribution to journalArticle

Chiaretti, Sabina ; Li, Xiaochun ; Gentleman, Robert ; Vitale, Antonella ; Vignetti, Marco ; Mandelli, Franco ; Ritz, Jerome ; Foa, Robin. / Gene expression profile of adult T-cell acute lymphocytic leukemia identifies distinct subsets of patients with different response to therapy and survival. In: Blood. 2004 ; Vol. 103, No. 7. pp. 2771-2778.
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