Gene Regulation

M. W. White, William Sullivan, M. S. Behnke, J. R. Radke

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

This chapter reviews the current understanding of the Toxoplasma transcriptome as it changes during the parasite intermediate life cycle. The chapter discusses the evidence that Toxoplasma possesses a similar repertoire of mechanisms to regulate transcription as observed in other well-studied eukaryotes, from yeast to multicellular animals. Given the importance of Toxoplasma infections to human populations, understanding developmental mechanisms initiated by sporozoites or bradyzoites leading to tissue cyst formation will be central to ultimately controlling transmission and chronic disease. Studies of Toxoplasma primary infections in animals and of sporozoite- and bradyzoite-infected cultures in vitro indicate that development initiated by either the sporozoite or bradyzoite stage is similar, and likely the consequence of a unified genetic program. Thus, defining the changes in gene expression that accompany this development pathway will be important to understand the underlying mechanisms responsible for toxoplasmosis caused by either route of infection. © 2007

Original languageEnglish
Title of host publicationToxoplasma Gondii
PublisherElsevier Ltd
Pages419-443
Number of pages25
ISBN (Print)9780123695420
DOIs
StatePublished - 2007

Fingerprint

Toxoplasma
sporozoites
Sporozoites
toxoplasmosis
bradyzoites
Genes
genes
Infection
chronic diseases
transcriptome
in vitro culture
human population
infection
eukaryotic cells
life cycle (organisms)
Toxoplasmosis
animals
transcription (genetics)
Life Cycle Stages
Eukaryota

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

White, M. W., Sullivan, W., Behnke, M. S., & Radke, J. R. (2007). Gene Regulation. In Toxoplasma Gondii (pp. 419-443). Elsevier Ltd. https://doi.org/10.1016/B978-012369542-0/50018-0

Gene Regulation. / White, M. W.; Sullivan, William; Behnke, M. S.; Radke, J. R.

Toxoplasma Gondii. Elsevier Ltd, 2007. p. 419-443.

Research output: Chapter in Book/Report/Conference proceedingChapter

White, MW, Sullivan, W, Behnke, MS & Radke, JR 2007, Gene Regulation. in Toxoplasma Gondii. Elsevier Ltd, pp. 419-443. https://doi.org/10.1016/B978-012369542-0/50018-0
White MW, Sullivan W, Behnke MS, Radke JR. Gene Regulation. In Toxoplasma Gondii. Elsevier Ltd. 2007. p. 419-443 https://doi.org/10.1016/B978-012369542-0/50018-0
White, M. W. ; Sullivan, William ; Behnke, M. S. ; Radke, J. R. / Gene Regulation. Toxoplasma Gondii. Elsevier Ltd, 2007. pp. 419-443
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