Gene therapy and endothelial cell targeting for cancer

R. R. Evans, T. P. Calmels, B. R. Pitt, Margaret Schwarz, C. S. Johnson, R. A. Modzelewski, J. S. Lazo

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The endothelium represents a potentially critical target for gene therapy because of its anatomical location and its importance in the viability in both normal and malignant tissues. Protecting the endothelium of normal tissues, such as the lungs, from the toxic effects of current antineoplastic agents and the destruction of the tumor vasculature are reasonable goals. As a target, however, the endothelium continues to represent a significant challenge. While gene delivery to cultured endothelial cells is possible, improved delivery systems are required, as well as cell-specific promoters, before in vivo gene therapy to important endothelial populations can be accomplished.

Original languageEnglish (US)
Pages (from-to)257-264
Number of pages8
JournalAnnals of the New York Academy of Sciences
Volume716
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Gene therapy
Endothelial cells
Genetic Therapy
Endothelium
Endothelial Cells
Tissue
Poisons
Antineoplastic Agents
Tumors
Neoplasms
Genes
Cultured Cells
Lung
Population
Cells
Cancer
Gene Therapy
Destruction
Gene

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Evans, R. R., Calmels, T. P., Pitt, B. R., Schwarz, M., Johnson, C. S., Modzelewski, R. A., & Lazo, J. S. (1994). Gene therapy and endothelial cell targeting for cancer. Annals of the New York Academy of Sciences, 716, 257-264. https://doi.org/10.1111/j.1749-6632.1994.tb21717.x

Gene therapy and endothelial cell targeting for cancer. / Evans, R. R.; Calmels, T. P.; Pitt, B. R.; Schwarz, Margaret; Johnson, C. S.; Modzelewski, R. A.; Lazo, J. S.

In: Annals of the New York Academy of Sciences, Vol. 716, 1994, p. 257-264.

Research output: Contribution to journalArticle

Evans, RR, Calmels, TP, Pitt, BR, Schwarz, M, Johnson, CS, Modzelewski, RA & Lazo, JS 1994, 'Gene therapy and endothelial cell targeting for cancer', Annals of the New York Academy of Sciences, vol. 716, pp. 257-264. https://doi.org/10.1111/j.1749-6632.1994.tb21717.x
Evans, R. R. ; Calmels, T. P. ; Pitt, B. R. ; Schwarz, Margaret ; Johnson, C. S. ; Modzelewski, R. A. ; Lazo, J. S. / Gene therapy and endothelial cell targeting for cancer. In: Annals of the New York Academy of Sciences. 1994 ; Vol. 716. pp. 257-264.
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