Gene therapy for articular cartilage repair

Stephen Trippel, M. Cucchiarini, H. Madry, S. Shi, C. Wang

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Articular cartilage serves as the gliding surface of joints. It is susceptible to damage from trauma and from degenerative diseases. Restoration of damaged articular cartilage may be achievable through the use of cell-regulatory molecules that augment the reparative activities of the cells, inhibit the cells' degradative activities, or both. A variety of such molecules have been identified. These include insulin-like growth factor 1, fibroblast growth factor 2, bone morphogenetic proteins 2, 4, and 7, and interleukin-1 receptor antagonist. It is now possible to transfer the genes encoding such molecules into articular cartilage and synovial lining cells. Although preliminary, data from in-vitro and in-vivo studies suggest that gene therapy can deliver such potentially therapeutic agents to protect existing cartilage and to build new cartilage.

Original languageEnglish
Pages (from-to)451-459
Number of pages9
JournalProceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine
Volume221
Issue number5
DOIs
StatePublished - 2007

Fingerprint

Gene therapy
Cartilage
Repair
Molecules
Gene encoding
Insulin
Fibroblasts
Linings
Restoration
Bone
Cells
Proteins

Keywords

  • Animal models
  • Arthritis
  • Articular cartilage
  • Gene therapy
  • Vectors

ASJC Scopus subject areas

  • Biomedical Engineering
  • Mechanical Engineering

Cite this

Gene therapy for articular cartilage repair. / Trippel, Stephen; Cucchiarini, M.; Madry, H.; Shi, S.; Wang, C.

In: Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, Vol. 221, No. 5, 2007, p. 451-459.

Research output: Contribution to journalArticle

Trippel, Stephen ; Cucchiarini, M. ; Madry, H. ; Shi, S. ; Wang, C. / Gene therapy for articular cartilage repair. In: Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine. 2007 ; Vol. 221, No. 5. pp. 451-459.
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