Gene therapy for articular cartilage repair

S. Trippell, M. Cucchiarini, H. Madry, S. Shi, C. Wang

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Articular cartilage serves as the gliding surface of joints. It is susceptible to damage from trauma and from degenerative diseases. Restoration of damaged articular cartilage may be achievable through the use of cell-regulatory molecules that augment the reparative activities of the cells, inhibit the cells' degradative activities, or both. A variety of such molecules have been identified. These include insulin-like growth factor 1, fibroblast growth factor 2, bone morphogenetic proteins 2, 4, and 7, and interleukin-1 receptor antagonist. It is now possible to transfer the genes encoding such molecules into articular cartilage and synovial lining cells. Although preliminary, data from in-vitro and in-vivo studies suggest that gene therapy can deliver such potentially therapeutic agents to protect existing cartilage and to build new cartilage.

Original languageEnglish (US)
Pages (from-to)451-459
Number of pages9
JournalProceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine
Volume221
Issue number5
DOIs
StatePublished - Aug 28 2007

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Keywords

  • Animal models
  • Arthritis
  • Articular cartilage
  • Gene therapy
  • Vectors

ASJC Scopus subject areas

  • Biomedical Engineering
  • Mechanical Engineering

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