Gentherapie bei gastrointestinalen tumoren am beispiel des pankreaskarzinoms: Standortbestimmung und perspektiven

Translated title of the contribution: Gene therapy in patients with gastrointestinal tumors taking pancreatic carcinomas as an example: State of the art and perspectives

J. Kleeff, H. Friess, M. Korc, M. W. Büchler

Research output: Contribution to journalReview article

Abstract

Gene therapy for gastrointestinal cancers has evolved from basic research to first clinical trials. This progress is due to improvements in gene transfer techniques and advances in the understanding of the molecular basis of gastrointestinal cancers. A better characterization of molecular alterations allows for the identification of molecular targets which are amenable for therapeutic interventions. Gene therapy involves the transfer of genetic material into cancer cells, which alters their neoplastic potential. Vectors used in gene transfer include viral and nonviral systems. Advances in gene transfer techniques and identification of specific molecular targets promise to lead a progress in the treatment of gastrointestinal carcinomas.

Original languageGerman
Pages (from-to)181-187
Number of pages7
JournalChirurgische Gastroenterologie mit Interdisziplinaren Gesprachen
Volume15
Issue number2
DOIs
StatePublished - Jul 28 1999

Fingerprint

Gene Transfer Techniques
Gastrointestinal Neoplasms
Genetic Therapy
Genes
Neoplasms
Clinical Trials
Carcinoma
Therapeutics
Research
Pancreatic Carcinoma

Keywords

  • Gene therapy
  • Gene transfer
  • Molecularbiologi Pancreatic carcinoma

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

Cite this

Gentherapie bei gastrointestinalen tumoren am beispiel des pankreaskarzinoms : Standortbestimmung und perspektiven. / Kleeff, J.; Friess, H.; Korc, M.; Büchler, M. W.

In: Chirurgische Gastroenterologie mit Interdisziplinaren Gesprachen, Vol. 15, No. 2, 28.07.1999, p. 181-187.

Research output: Contribution to journalReview article

@article{830364b2179f4be8823ec037a98c04e6,
title = "Gentherapie bei gastrointestinalen tumoren am beispiel des pankreaskarzinoms: Standortbestimmung und perspektiven",
abstract = "Gene therapy for gastrointestinal cancers has evolved from basic research to first clinical trials. This progress is due to improvements in gene transfer techniques and advances in the understanding of the molecular basis of gastrointestinal cancers. A better characterization of molecular alterations allows for the identification of molecular targets which are amenable for therapeutic interventions. Gene therapy involves the transfer of genetic material into cancer cells, which alters their neoplastic potential. Vectors used in gene transfer include viral and nonviral systems. Advances in gene transfer techniques and identification of specific molecular targets promise to lead a progress in the treatment of gastrointestinal carcinomas.",
keywords = "Gene therapy, Gene transfer, Molecularbiologi Pancreatic carcinoma",
author = "J. Kleeff and H. Friess and M. Korc and B{\"u}chler, {M. W.}",
year = "1999",
month = "7",
day = "28",
doi = "10.1159/000012551",
language = "German",
volume = "15",
pages = "181--187",
journal = "Visceral Medicine",
issn = "2297-4725",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Gentherapie bei gastrointestinalen tumoren am beispiel des pankreaskarzinoms

T2 - Standortbestimmung und perspektiven

AU - Kleeff, J.

AU - Friess, H.

AU - Korc, M.

AU - Büchler, M. W.

PY - 1999/7/28

Y1 - 1999/7/28

N2 - Gene therapy for gastrointestinal cancers has evolved from basic research to first clinical trials. This progress is due to improvements in gene transfer techniques and advances in the understanding of the molecular basis of gastrointestinal cancers. A better characterization of molecular alterations allows for the identification of molecular targets which are amenable for therapeutic interventions. Gene therapy involves the transfer of genetic material into cancer cells, which alters their neoplastic potential. Vectors used in gene transfer include viral and nonviral systems. Advances in gene transfer techniques and identification of specific molecular targets promise to lead a progress in the treatment of gastrointestinal carcinomas.

AB - Gene therapy for gastrointestinal cancers has evolved from basic research to first clinical trials. This progress is due to improvements in gene transfer techniques and advances in the understanding of the molecular basis of gastrointestinal cancers. A better characterization of molecular alterations allows for the identification of molecular targets which are amenable for therapeutic interventions. Gene therapy involves the transfer of genetic material into cancer cells, which alters their neoplastic potential. Vectors used in gene transfer include viral and nonviral systems. Advances in gene transfer techniques and identification of specific molecular targets promise to lead a progress in the treatment of gastrointestinal carcinomas.

KW - Gene therapy

KW - Gene transfer

KW - Molecularbiologi Pancreatic carcinoma

UR - http://www.scopus.com/inward/record.url?scp=0032804496&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032804496&partnerID=8YFLogxK

U2 - 10.1159/000012551

DO - 10.1159/000012551

M3 - Review article

AN - SCOPUS:0032804496

VL - 15

SP - 181

EP - 187

JO - Visceral Medicine

JF - Visceral Medicine

SN - 2297-4725

IS - 2

ER -