Gene therapy strategies for leukemia

S. E. Braun, K. Chen, M. Battiwalla, K. Cornetta

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

A number of diverse gene therapy strategies are being evaluated in the search for novel therapeutic approaches to leukemia. Antisense oligonucleotides, ribozymes and retroviral vectors are approaches directed at the molecular mechanisms of cancer. Transfer of genes encoding cytokines and human leukocyte antigens (HLAs) could also be used to elicit immunity against tumor cells. Gene marking strategies have been useful in elucidating the biology of disease relapse after autologous bone marrow transplantation. Suicide genes, such as the herpes simplex thymidine kinase gene, have been used to modulate graft-versus-host disease after allogeneic bone marrow transplantation. Although gene delivery remains a major challenge to gene therapy, some modifications have been implemented to overcome this issue. This review will summarize these gene therapy strategies aimed at increasing the survival of patients with leukemia.

Original languageEnglish (US)
Pages (from-to)39-46
Number of pages8
JournalMolecular Medicine Today
Volume3
Issue number1
DOIs
StatePublished - Dec 1 1997

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics

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