Generalizability of the nonalcoholic steatohepatitis clinical research network histologic scoring system for nonalcoholic fatty liver disease

Ravi Juluri, Raj Vuppalanchi, John Olson, Aynur Ünalp, Mark L. Van Natta, Oscar Cummings, James Tonascia, Naga Chalasani

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

GOALS AND BACKGROUND: The recently developed histologic scoring system for nonalcoholic fatty liver disease (NAFLD) by the nonalcoholic steatohepatitis (NASH) Clinical Research Network (CRN) is becoming increasingly popular. However, its generalizability to a community setting has not been evaluated. We conducted a study to compare a community general pathologist to an expert hepatopathologist in assessing NAFLD using the NASH CRN scoring system. STUDY: Forty-eight consecutive patients with suspected NAFLD underwent liver biopsy. Histologic features of interest such as steatosis, lobular inflammation, balloon degeneration, fibrosis, NAFLD Activity Score (NAS), and the presence of NASH were scored in a blinded fashion by the 2 pathologists on 2 separate occasions 3 months apart. RESULTS: The mean (±SD) length of the liver biopsy samples was 25±5 mm. Interobserver agreement (κ) between 2 pathologists was 0.62 (0.45-0.80) for steatosis, 0.44 (0.23-0.65) for lobular inflammation, 0.25 (0.11-0.38) for ballooning, 0.40 for NAS (0.28-0.52), and 0.35 (0.19-0.52) for fibrosis. The 2 pathologists diagnosed "definite NASH" in a similar proportion of patients (56% vs. 57%), but their interobserver agreement was only 0.46 (0.24-0.67) as they both diagnosed different levels of NASH (borderline vs. definite) in different subjects. Intraobserver agreement was generally comparable for steatosis, lobular inflammation, NAS, and diagnosis of NASH, but not for fibrosis. CONCLUSIONS: Clinically important differences exist between community general pathologist and expert hepatopathologist in assessing NAFLD using the NASH CRN scoring system. More studies are needed to investigate its suitability for community-based clinical practice.

Original languageEnglish
Pages (from-to)55-58
Number of pages4
JournalJournal of Clinical Gastroenterology
Volume45
Issue number1
DOIs
StatePublished - Jan 2011

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Research
Fibrosis
Non-alcoholic Fatty Liver Disease
Inflammation
Biopsy
Liver
Pathologists

Keywords

  • liver biopsy
  • nonalcoholic steatohepatitis
  • sampling error

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Generalizability of the nonalcoholic steatohepatitis clinical research network histologic scoring system for nonalcoholic fatty liver disease. / Juluri, Ravi; Vuppalanchi, Raj; Olson, John; Ünalp, Aynur; Van Natta, Mark L.; Cummings, Oscar; Tonascia, James; Chalasani, Naga.

In: Journal of Clinical Gastroenterology, Vol. 45, No. 1, 01.2011, p. 55-58.

Research output: Contribution to journalArticle

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