Generation of a syngeneic orthotopic transplant model of prostate cancer metastasis

Leigh Ellis, Kristin Lehet, Sheng Yu Ku, Gissou Azabdaftari, Roberto Pili

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Progression to metastatic disease is the primary cause of mortality in men with prostate cancer (PCa). Mouse models which progress with spontaneous metastasis are limited. Such models would allow for extensive studies of molecular mechanisms of metastasis, and more definite pre- clinical therapy trials. Orthotopic murine models have been described; however a limiting biology of these models is their lack of an intact immune system. Within, we describe the development of an androgen sensitive and castrate resistant tractable orthotopic murine syngeneic (immune competent) model of prostate cancer. Both models develop primary tumors which spontaneously progress to metastatic disease in lymph tissue. These models will allow for more complete mechanistic and therapeutic studies in a short time period.

Original languageEnglish (US)
Pages (from-to)609-613
Number of pages5
JournalOncoscience
Volume1
Issue number10
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • Castrate resistant prostate cancer
  • MYC
  • Metastasis
  • Mouse models
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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