Genes and environment in neonatal intraventricular hemorrhage

Laura R. Ment, Ulrika Ådén, Charles R. Bauer, Henrietta S. Bada, Waldemar A. Carlo, Jeffrey R. Kaiser, Aiping Lin, Charles Michael Cotten, Jeffrey Murray, Grier Page, Mikko Hallman, Richard P. Lifton, Heping Zhang, Cindy Bryant, Christopher Cassady, Carmen Garcia, Yvette R. Johnson, Heidi E. Karpen, Martha M. Munden, Geneva Shores & 168 others John Cassese, Angelita M. Hensman, Elisa Vieira, Betty Vohr, Michael Wallach, James J. Cummings, Scott S. MacGilvray, Sherry Moseley, Vickie Trapanotto, Brenda Poindexter, Leslie Dawn Wilson, Shirley Wright-Coltart, Marco Bartocci, Gordana Printz, Andrew Hopper, Leon Smith, Beverly P. Wood, Lionel Young, Walter C. Allan, Jessica Alfsson, Karin Sävman, Stuart A. Royal, Daniel W. Young, Shirley Cosby, Crystal Helms, Teresita Angtuaco, N. Carol Sikes, Melanie J. Mason, R. Whit Hall, Henrietta Bada, Harigovinda R. Challa, Deborah L. Grider, Vesna Kriss, Vicki Whitehead, George Abdenour, Charles Bauer, Gary Danton, Daniel Montesinos, Saigal Gaurav, Willy Philias, Uygar Teomete, John Barks, Mary Christensen, Ramon Sanchez, Makayla Sieg, Stephanie Wiggins, Janell Fuller, Carol Hartenberger, Rebecca Montman, Jessica B. Williams, Susan Williamson, Carl Bose, Cynthia L. Clark, Matthew Laughon, Soraya Abbasi, Noah M. Cook, Toni Mancini, Aasma Chaudhary, Christopher DeMauro, Barbara Schmidt, Ellen Dean, Fabien Eyal, Paul Maertens, Thomas F. Boulden, Harris L. Cohen, Shelia Dempsey, Pam LeNoue, Massroor Pourcyrous, Karie Bird, Roger G. Faix, Gary Hedlund, Kevin Moore, Karen Osborne, Kimberlee Weaver-Lewis, Bradley A. Yoder, Dennis E. Mayock, Manjiri Dighe, Patricia L. Brown, T. Michael O'Shea, Nancy Peters, Terrie Inder, Karen Lukas, Amit Mathur, Robert McKinstry, Joshua Shimony, Aparna Joshi, Jay Ann Nelson, Seetha Shankaran, Eunice H. Woldt, Kenneth Baker, Matthew J. Bizzarro, Murim Choi, Richard Ehrenkranz, Anita Farhi, T. R. Goodman, Karol Katz, Monica Konstantino, Zhifa Liu, Jill Maller-Kesselman, Carol Nelson-Williams, Xiaoyi Min, Michele C. Walsh, Avroy A. Fanaroff, Nancy S. Newman, Bonnie S. Siner, Kurt Schibler, Edward F. Donovan, Vivek Narendran, Barbara Alexander, Cathy Grisby, Jody Hessling, Marcia Worley Mersmann, Holly L. Mincey, C. Michael Cotten, Ronald N. Goldberg, Kathy J. Auten, Barbara J. Stoll, Ellen C. Hale, Rosemary D. Higgins, Linda L. Wright, Sumner J. Yaffe, Elizabeth M. McClure, Stephanie Wilson Archer, Abhik Das, Scott A. McDonald, W. Kenneth Poole, Betty K. Hastings, Jeanette O'Donnell Auman, Kristin M. Zaterka-Baxter, Krisa P. Van Meurs, David K. Stevenson, M. Bethany Ball, Namasivayam Ambalavanan, Monica V. Collins, Shirley S. Cosby, Neil N. Finer, Maynard R. Rasmussen, David Kaegi, Kathy Arnell, Clarence Demetrio, Wade Rich, Edward F. Bell, Karen J. Johnson, Jeffrey C. Murray, Shahnaz Duara, Ruth Everett-Thomas, Sheldon B. Korones, Tina Hudson, Pablo J. Sánchez, Abbot R. Laptook, Walid A. Salhab, Susie Madison, Nancy A. Miller, Gaynelle Hensley, Alicia Guzman, Kathleen A. Kennedy, Jon E. Tyson, Esther G. Akpa, Patty A. Cluff, Claudia I. Franco, Anna E. Lis, Georgia E. McDavid, Patti Pierce Tate, Beena G. Sood, G. Ganesh Konduri, Rebecca Bara, Geraldine Muran, Alan H. Jobe

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.

Original languageEnglish (US)
Pages (from-to)592-603
Number of pages12
JournalSeminars in Perinatology
Volume39
Issue number8
DOIs
StatePublished - Dec 1 2015

Fingerprint

Hemorrhage
Cerebrovascular Circulation
Newborn Infant
Genome
Genes
Gene-Environment Interaction
Very Low Birth Weight Infant
Genome-Wide Association Study
Statistical Factor Analysis
Blood Vessels
Inflammation

Keywords

  • Genes
  • GWAS
  • Intraventricular hemorrhage
  • Neonate
  • Preterm

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Ment, L. R., Ådén, U., Bauer, C. R., Bada, H. S., Carlo, W. A., Kaiser, J. R., ... Jobe, A. H. (2015). Genes and environment in neonatal intraventricular hemorrhage. Seminars in Perinatology, 39(8), 592-603. https://doi.org/10.1053/j.semperi.2015.09.006

Genes and environment in neonatal intraventricular hemorrhage. / Ment, Laura R.; Ådén, Ulrika; Bauer, Charles R.; Bada, Henrietta S.; Carlo, Waldemar A.; Kaiser, Jeffrey R.; Lin, Aiping; Cotten, Charles Michael; Murray, Jeffrey; Page, Grier; Hallman, Mikko; Lifton, Richard P.; Zhang, Heping; Bryant, Cindy; Cassady, Christopher; Garcia, Carmen; Johnson, Yvette R.; Karpen, Heidi E.; Munden, Martha M.; Shores, Geneva; Cassese, John; Hensman, Angelita M.; Vieira, Elisa; Vohr, Betty; Wallach, Michael; Cummings, James J.; MacGilvray, Scott S.; Moseley, Sherry; Trapanotto, Vickie; Poindexter, Brenda; Wilson, Leslie Dawn; Wright-Coltart, Shirley; Bartocci, Marco; Printz, Gordana; Hopper, Andrew; Smith, Leon; Wood, Beverly P.; Young, Lionel; Allan, Walter C.; Alfsson, Jessica; Sävman, Karin; Royal, Stuart A.; Young, Daniel W.; Cosby, Shirley; Helms, Crystal; Angtuaco, Teresita; Carol Sikes, N.; Mason, Melanie J.; Whit Hall, R.; Bada, Henrietta; Challa, Harigovinda R.; Grider, Deborah L.; Kriss, Vesna; Whitehead, Vicki; Abdenour, George; Bauer, Charles; Danton, Gary; Montesinos, Daniel; Gaurav, Saigal; Philias, Willy; Teomete, Uygar; Barks, John; Christensen, Mary; Sanchez, Ramon; Sieg, Makayla; Wiggins, Stephanie; Fuller, Janell; Hartenberger, Carol; Montman, Rebecca; Williams, Jessica B.; Williamson, Susan; Bose, Carl; Clark, Cynthia L.; Laughon, Matthew; Abbasi, Soraya; Cook, Noah M.; Mancini, Toni; Chaudhary, Aasma; DeMauro, Christopher; Schmidt, Barbara; Dean, Ellen; Eyal, Fabien; Maertens, Paul; Boulden, Thomas F.; Cohen, Harris L.; Dempsey, Shelia; LeNoue, Pam; Pourcyrous, Massroor; Bird, Karie; Faix, Roger G.; Hedlund, Gary; Moore, Kevin; Osborne, Karen; Weaver-Lewis, Kimberlee; Yoder, Bradley A.; Mayock, Dennis E.; Dighe, Manjiri; Brown, Patricia L.; Michael O'Shea, T.; Peters, Nancy; Inder, Terrie; Lukas, Karen; Mathur, Amit; McKinstry, Robert; Shimony, Joshua; Joshi, Aparna; Ann Nelson, Jay; Shankaran, Seetha; Woldt, Eunice H.; Baker, Kenneth; Bizzarro, Matthew J.; Choi, Murim; Ehrenkranz, Richard; Farhi, Anita; Goodman, T. R.; Katz, Karol; Konstantino, Monica; Liu, Zhifa; Maller-Kesselman, Jill; Nelson-Williams, Carol; Min, Xiaoyi; Walsh, Michele C.; Fanaroff, Avroy A.; Newman, Nancy S.; Siner, Bonnie S.; Schibler, Kurt; Donovan, Edward F.; Narendran, Vivek; Alexander, Barbara; Grisby, Cathy; Hessling, Jody; Mersmann, Marcia Worley; Mincey, Holly L.; Michael Cotten, C.; Goldberg, Ronald N.; Auten, Kathy J.; Stoll, Barbara J.; Hale, Ellen C.; Higgins, Rosemary D.; Wright, Linda L.; Yaffe, Sumner J.; McClure, Elizabeth M.; Archer, Stephanie Wilson; Das, Abhik; McDonald, Scott A.; Poole, W. Kenneth; Hastings, Betty K.; O'Donnell Auman, Jeanette; Zaterka-Baxter, Kristin M.; Van Meurs, Krisa P.; Stevenson, David K.; Ball, M. Bethany; Ambalavanan, Namasivayam; Collins, Monica V.; Cosby, Shirley S.; Finer, Neil N.; Rasmussen, Maynard R.; Kaegi, David; Arnell, Kathy; Demetrio, Clarence; Rich, Wade; Bell, Edward F.; Johnson, Karen J.; Murray, Jeffrey C.; Duara, Shahnaz; Everett-Thomas, Ruth; Korones, Sheldon B.; Hudson, Tina; Sánchez, Pablo J.; Laptook, Abbot R.; Salhab, Walid A.; Madison, Susie; Miller, Nancy A.; Hensley, Gaynelle; Guzman, Alicia; Kennedy, Kathleen A.; Tyson, Jon E.; Akpa, Esther G.; Cluff, Patty A.; Franco, Claudia I.; Lis, Anna E.; McDavid, Georgia E.; Tate, Patti Pierce; Sood, Beena G.; Ganesh Konduri, G.; Bara, Rebecca; Muran, Geraldine; Jobe, Alan H.

In: Seminars in Perinatology, Vol. 39, No. 8, 01.12.2015, p. 592-603.

Research output: Contribution to journalArticle

Ment, LR, Ådén, U, Bauer, CR, Bada, HS, Carlo, WA, Kaiser, JR, Lin, A, Cotten, CM, Murray, J, Page, G, Hallman, M, Lifton, RP, Zhang, H, Bryant, C, Cassady, C, Garcia, C, Johnson, YR, Karpen, HE, Munden, MM, Shores, G, Cassese, J, Hensman, AM, Vieira, E, Vohr, B, Wallach, M, Cummings, JJ, MacGilvray, SS, Moseley, S, Trapanotto, V, Poindexter, B, Wilson, LD, Wright-Coltart, S, Bartocci, M, Printz, G, Hopper, A, Smith, L, Wood, BP, Young, L, Allan, WC, Alfsson, J, Sävman, K, Royal, SA, Young, DW, Cosby, S, Helms, C, Angtuaco, T, Carol Sikes, N, Mason, MJ, Whit Hall, R, Bada, H, Challa, HR, Grider, DL, Kriss, V, Whitehead, V, Abdenour, G, Bauer, C, Danton, G, Montesinos, D, Gaurav, S, Philias, W, Teomete, U, Barks, J, Christensen, M, Sanchez, R, Sieg, M, Wiggins, S, Fuller, J, Hartenberger, C, Montman, R, Williams, JB, Williamson, S, Bose, C, Clark, CL, Laughon, M, Abbasi, S, Cook, NM, Mancini, T, Chaudhary, A, DeMauro, C, Schmidt, B, Dean, E, Eyal, F, Maertens, P, Boulden, TF, Cohen, HL, Dempsey, S, LeNoue, P, Pourcyrous, M, Bird, K, Faix, RG, Hedlund, G, Moore, K, Osborne, K, Weaver-Lewis, K, Yoder, BA, Mayock, DE, Dighe, M, Brown, PL, Michael O'Shea, T, Peters, N, Inder, T, Lukas, K, Mathur, A, McKinstry, R, Shimony, J, Joshi, A, Ann Nelson, J, Shankaran, S, Woldt, EH, Baker, K, Bizzarro, MJ, Choi, M, Ehrenkranz, R, Farhi, A, Goodman, TR, Katz, K, Konstantino, M, Liu, Z, Maller-Kesselman, J, Nelson-Williams, C, Min, X, Walsh, MC, Fanaroff, AA, Newman, NS, Siner, BS, Schibler, K, Donovan, EF, Narendran, V, Alexander, B, Grisby, C, Hessling, J, Mersmann, MW, Mincey, HL, Michael Cotten, C, Goldberg, RN, Auten, KJ, Stoll, BJ, Hale, EC, Higgins, RD, Wright, LL, Yaffe, SJ, McClure, EM, Archer, SW, Das, A, McDonald, SA, Poole, WK, Hastings, BK, O'Donnell Auman, J, Zaterka-Baxter, KM, Van Meurs, KP, Stevenson, DK, Ball, MB, Ambalavanan, N, Collins, MV, Cosby, SS, Finer, NN, Rasmussen, MR, Kaegi, D, Arnell, K, Demetrio, C, Rich, W, Bell, EF, Johnson, KJ, Murray, JC, Duara, S, Everett-Thomas, R, Korones, SB, Hudson, T, Sánchez, PJ, Laptook, AR, Salhab, WA, Madison, S, Miller, NA, Hensley, G, Guzman, A, Kennedy, KA, Tyson, JE, Akpa, EG, Cluff, PA, Franco, CI, Lis, AE, McDavid, GE, Tate, PP, Sood, BG, Ganesh Konduri, G, Bara, R, Muran, G & Jobe, AH 2015, 'Genes and environment in neonatal intraventricular hemorrhage', Seminars in Perinatology, vol. 39, no. 8, pp. 592-603. https://doi.org/10.1053/j.semperi.2015.09.006
Ment LR, Ådén U, Bauer CR, Bada HS, Carlo WA, Kaiser JR et al. Genes and environment in neonatal intraventricular hemorrhage. Seminars in Perinatology. 2015 Dec 1;39(8):592-603. https://doi.org/10.1053/j.semperi.2015.09.006
Ment, Laura R. ; Ådén, Ulrika ; Bauer, Charles R. ; Bada, Henrietta S. ; Carlo, Waldemar A. ; Kaiser, Jeffrey R. ; Lin, Aiping ; Cotten, Charles Michael ; Murray, Jeffrey ; Page, Grier ; Hallman, Mikko ; Lifton, Richard P. ; Zhang, Heping ; Bryant, Cindy ; Cassady, Christopher ; Garcia, Carmen ; Johnson, Yvette R. ; Karpen, Heidi E. ; Munden, Martha M. ; Shores, Geneva ; Cassese, John ; Hensman, Angelita M. ; Vieira, Elisa ; Vohr, Betty ; Wallach, Michael ; Cummings, James J. ; MacGilvray, Scott S. ; Moseley, Sherry ; Trapanotto, Vickie ; Poindexter, Brenda ; Wilson, Leslie Dawn ; Wright-Coltart, Shirley ; Bartocci, Marco ; Printz, Gordana ; Hopper, Andrew ; Smith, Leon ; Wood, Beverly P. ; Young, Lionel ; Allan, Walter C. ; Alfsson, Jessica ; Sävman, Karin ; Royal, Stuart A. ; Young, Daniel W. ; Cosby, Shirley ; Helms, Crystal ; Angtuaco, Teresita ; Carol Sikes, N. ; Mason, Melanie J. ; Whit Hall, R. ; Bada, Henrietta ; Challa, Harigovinda R. ; Grider, Deborah L. ; Kriss, Vesna ; Whitehead, Vicki ; Abdenour, George ; Bauer, Charles ; Danton, Gary ; Montesinos, Daniel ; Gaurav, Saigal ; Philias, Willy ; Teomete, Uygar ; Barks, John ; Christensen, Mary ; Sanchez, Ramon ; Sieg, Makayla ; Wiggins, Stephanie ; Fuller, Janell ; Hartenberger, Carol ; Montman, Rebecca ; Williams, Jessica B. ; Williamson, Susan ; Bose, Carl ; Clark, Cynthia L. ; Laughon, Matthew ; Abbasi, Soraya ; Cook, Noah M. ; Mancini, Toni ; Chaudhary, Aasma ; DeMauro, Christopher ; Schmidt, Barbara ; Dean, Ellen ; Eyal, Fabien ; Maertens, Paul ; Boulden, Thomas F. ; Cohen, Harris L. ; Dempsey, Shelia ; LeNoue, Pam ; Pourcyrous, Massroor ; Bird, Karie ; Faix, Roger G. ; Hedlund, Gary ; Moore, Kevin ; Osborne, Karen ; Weaver-Lewis, Kimberlee ; Yoder, Bradley A. ; Mayock, Dennis E. ; Dighe, Manjiri ; Brown, Patricia L. ; Michael O'Shea, T. ; Peters, Nancy ; Inder, Terrie ; Lukas, Karen ; Mathur, Amit ; McKinstry, Robert ; Shimony, Joshua ; Joshi, Aparna ; Ann Nelson, Jay ; Shankaran, Seetha ; Woldt, Eunice H. ; Baker, Kenneth ; Bizzarro, Matthew J. ; Choi, Murim ; Ehrenkranz, Richard ; Farhi, Anita ; Goodman, T. R. ; Katz, Karol ; Konstantino, Monica ; Liu, Zhifa ; Maller-Kesselman, Jill ; Nelson-Williams, Carol ; Min, Xiaoyi ; Walsh, Michele C. ; Fanaroff, Avroy A. ; Newman, Nancy S. ; Siner, Bonnie S. ; Schibler, Kurt ; Donovan, Edward F. ; Narendran, Vivek ; Alexander, Barbara ; Grisby, Cathy ; Hessling, Jody ; Mersmann, Marcia Worley ; Mincey, Holly L. ; Michael Cotten, C. ; Goldberg, Ronald N. ; Auten, Kathy J. ; Stoll, Barbara J. ; Hale, Ellen C. ; Higgins, Rosemary D. ; Wright, Linda L. ; Yaffe, Sumner J. ; McClure, Elizabeth M. ; Archer, Stephanie Wilson ; Das, Abhik ; McDonald, Scott A. ; Poole, W. Kenneth ; Hastings, Betty K. ; O'Donnell Auman, Jeanette ; Zaterka-Baxter, Kristin M. ; Van Meurs, Krisa P. ; Stevenson, David K. ; Ball, M. Bethany ; Ambalavanan, Namasivayam ; Collins, Monica V. ; Cosby, Shirley S. ; Finer, Neil N. ; Rasmussen, Maynard R. ; Kaegi, David ; Arnell, Kathy ; Demetrio, Clarence ; Rich, Wade ; Bell, Edward F. ; Johnson, Karen J. ; Murray, Jeffrey C. ; Duara, Shahnaz ; Everett-Thomas, Ruth ; Korones, Sheldon B. ; Hudson, Tina ; Sánchez, Pablo J. ; Laptook, Abbot R. ; Salhab, Walid A. ; Madison, Susie ; Miller, Nancy A. ; Hensley, Gaynelle ; Guzman, Alicia ; Kennedy, Kathleen A. ; Tyson, Jon E. ; Akpa, Esther G. ; Cluff, Patty A. ; Franco, Claudia I. ; Lis, Anna E. ; McDavid, Georgia E. ; Tate, Patti Pierce ; Sood, Beena G. ; Ganesh Konduri, G. ; Bara, Rebecca ; Muran, Geraldine ; Jobe, Alan H. / Genes and environment in neonatal intraventricular hemorrhage. In: Seminars in Perinatology. 2015 ; Vol. 39, No. 8. pp. 592-603.
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title = "Genes and environment in neonatal intraventricular hemorrhage",
abstract = "Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.",
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TY - JOUR

T1 - Genes and environment in neonatal intraventricular hemorrhage

AU - Ment, Laura R.

AU - Ådén, Ulrika

AU - Bauer, Charles R.

AU - Bada, Henrietta S.

AU - Carlo, Waldemar A.

AU - Kaiser, Jeffrey R.

AU - Lin, Aiping

AU - Cotten, Charles Michael

AU - Murray, Jeffrey

AU - Page, Grier

AU - Hallman, Mikko

AU - Lifton, Richard P.

AU - Zhang, Heping

AU - Bryant, Cindy

AU - Cassady, Christopher

AU - Garcia, Carmen

AU - Johnson, Yvette R.

AU - Karpen, Heidi E.

AU - Munden, Martha M.

AU - Shores, Geneva

AU - Cassese, John

AU - Hensman, Angelita M.

AU - Vieira, Elisa

AU - Vohr, Betty

AU - Wallach, Michael

AU - Cummings, James J.

AU - MacGilvray, Scott S.

AU - Moseley, Sherry

AU - Trapanotto, Vickie

AU - Poindexter, Brenda

AU - Wilson, Leslie Dawn

AU - Wright-Coltart, Shirley

AU - Bartocci, Marco

AU - Printz, Gordana

AU - Hopper, Andrew

AU - Smith, Leon

AU - Wood, Beverly P.

AU - Young, Lionel

AU - Allan, Walter C.

AU - Alfsson, Jessica

AU - Sävman, Karin

AU - Royal, Stuart A.

AU - Young, Daniel W.

AU - Cosby, Shirley

AU - Helms, Crystal

AU - Angtuaco, Teresita

AU - Carol Sikes, N.

AU - Mason, Melanie J.

AU - Whit Hall, R.

AU - Bada, Henrietta

AU - Challa, Harigovinda R.

AU - Grider, Deborah L.

AU - Kriss, Vesna

AU - Whitehead, Vicki

AU - Abdenour, George

AU - Bauer, Charles

AU - Danton, Gary

AU - Montesinos, Daniel

AU - Gaurav, Saigal

AU - Philias, Willy

AU - Teomete, Uygar

AU - Barks, John

AU - Christensen, Mary

AU - Sanchez, Ramon

AU - Sieg, Makayla

AU - Wiggins, Stephanie

AU - Fuller, Janell

AU - Hartenberger, Carol

AU - Montman, Rebecca

AU - Williams, Jessica B.

AU - Williamson, Susan

AU - Bose, Carl

AU - Clark, Cynthia L.

AU - Laughon, Matthew

AU - Abbasi, Soraya

AU - Cook, Noah M.

AU - Mancini, Toni

AU - Chaudhary, Aasma

AU - DeMauro, Christopher

AU - Schmidt, Barbara

AU - Dean, Ellen

AU - Eyal, Fabien

AU - Maertens, Paul

AU - Boulden, Thomas F.

AU - Cohen, Harris L.

AU - Dempsey, Shelia

AU - LeNoue, Pam

AU - Pourcyrous, Massroor

AU - Bird, Karie

AU - Faix, Roger G.

AU - Hedlund, Gary

AU - Moore, Kevin

AU - Osborne, Karen

AU - Weaver-Lewis, Kimberlee

AU - Yoder, Bradley A.

AU - Mayock, Dennis E.

AU - Dighe, Manjiri

AU - Brown, Patricia L.

AU - Michael O'Shea, T.

AU - Peters, Nancy

AU - Inder, Terrie

AU - Lukas, Karen

AU - Mathur, Amit

AU - McKinstry, Robert

AU - Shimony, Joshua

AU - Joshi, Aparna

AU - Ann Nelson, Jay

AU - Shankaran, Seetha

AU - Woldt, Eunice H.

AU - Baker, Kenneth

AU - Bizzarro, Matthew J.

AU - Choi, Murim

AU - Ehrenkranz, Richard

AU - Farhi, Anita

AU - Goodman, T. R.

AU - Katz, Karol

AU - Konstantino, Monica

AU - Liu, Zhifa

AU - Maller-Kesselman, Jill

AU - Nelson-Williams, Carol

AU - Min, Xiaoyi

AU - Walsh, Michele C.

AU - Fanaroff, Avroy A.

AU - Newman, Nancy S.

AU - Siner, Bonnie S.

AU - Schibler, Kurt

AU - Donovan, Edward F.

AU - Narendran, Vivek

AU - Alexander, Barbara

AU - Grisby, Cathy

AU - Hessling, Jody

AU - Mersmann, Marcia Worley

AU - Mincey, Holly L.

AU - Michael Cotten, C.

AU - Goldberg, Ronald N.

AU - Auten, Kathy J.

AU - Stoll, Barbara J.

AU - Hale, Ellen C.

AU - Higgins, Rosemary D.

AU - Wright, Linda L.

AU - Yaffe, Sumner J.

AU - McClure, Elizabeth M.

AU - Archer, Stephanie Wilson

AU - Das, Abhik

AU - McDonald, Scott A.

AU - Poole, W. Kenneth

AU - Hastings, Betty K.

AU - O'Donnell Auman, Jeanette

AU - Zaterka-Baxter, Kristin M.

AU - Van Meurs, Krisa P.

AU - Stevenson, David K.

AU - Ball, M. Bethany

AU - Ambalavanan, Namasivayam

AU - Collins, Monica V.

AU - Cosby, Shirley S.

AU - Finer, Neil N.

AU - Rasmussen, Maynard R.

AU - Kaegi, David

AU - Arnell, Kathy

AU - Demetrio, Clarence

AU - Rich, Wade

AU - Bell, Edward F.

AU - Johnson, Karen J.

AU - Murray, Jeffrey C.

AU - Duara, Shahnaz

AU - Everett-Thomas, Ruth

AU - Korones, Sheldon B.

AU - Hudson, Tina

AU - Sánchez, Pablo J.

AU - Laptook, Abbot R.

AU - Salhab, Walid A.

AU - Madison, Susie

AU - Miller, Nancy A.

AU - Hensley, Gaynelle

AU - Guzman, Alicia

AU - Kennedy, Kathleen A.

AU - Tyson, Jon E.

AU - Akpa, Esther G.

AU - Cluff, Patty A.

AU - Franco, Claudia I.

AU - Lis, Anna E.

AU - McDavid, Georgia E.

AU - Tate, Patti Pierce

AU - Sood, Beena G.

AU - Ganesh Konduri, G.

AU - Bara, Rebecca

AU - Muran, Geraldine

AU - Jobe, Alan H.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.

AB - Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.

KW - Genes

KW - GWAS

KW - Intraventricular hemorrhage

KW - Neonate

KW - Preterm

UR - http://www.scopus.com/inward/record.url?scp=84946738462&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946738462&partnerID=8YFLogxK

U2 - 10.1053/j.semperi.2015.09.006

DO - 10.1053/j.semperi.2015.09.006

M3 - Article

VL - 39

SP - 592

EP - 603

JO - Seminars in Perinatology

JF - Seminars in Perinatology

SN - 0146-0005

IS - 8

ER -