Genes associate with abnormal bone cell activity in bone metastasis

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Bone is one of the most frequent sites of metastasis in patients with malignancies. Up to 90 % of patients with multiple myeloma, and 60 % to 75 % patients with prostate cancer and breast cancer develop bone metastasis at the later stages of their diseases. Bone metastases are responsible for tremendous morbidity in patients with cancer, including severe bone pain, pathologic fractures, spinal cord and nerve compression syndromes, life-threatening hypercalcemia, and increased mortality. Multiple factors produced by tumor cells or produced by the bone marrow microenvironment in response to tumor cells play important roles in activation of osteoclastic bone resorption and modulation of osteoblastic activity in patients with bone metastasis. In this chapter, we will review the genes that play important roles in bone destruction, tumor growth, and osteoblast activity in bone metastasis and discuss the potential therapies targeting the products of these genes to block both bone destruction and tumor growth.

Original languageEnglish
Pages (from-to)569-578
Number of pages10
JournalCancer and Metastasis Reviews
Volume31
Issue number3-4
DOIs
StatePublished - Dec 2012

Fingerprint

Neoplasm Metastasis
Bone and Bones
Genes
Neoplasms
Breast Neoplasms
Nerve Compression Syndromes
Spinal Nerves
Bone Neoplasms
Spontaneous Fractures
Spinal Cord Compression
Gene Targeting
Hypercalcemia
Bone Resorption
Growth
Osteoblasts
Multiple Myeloma
Prostatic Neoplasms
Bone Marrow
Morbidity
Pain

Keywords

  • Bone metastasis
  • Microenvironment
  • Myeloma
  • Osteoblasts
  • Osteoclasts

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Genes associate with abnormal bone cell activity in bone metastasis. / Roodman, G. David.

In: Cancer and Metastasis Reviews, Vol. 31, No. 3-4, 12.2012, p. 569-578.

Research output: Contribution to journalArticle

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