Genes contributing to the development of alcoholism

An overview

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Genetic factors (i.e., variations in specific genes) account for a substantial portion of the risk for alcoholism. However, identifying those genes and the specific variations involved is challenging. Researchers have used both case-control and family studies to identify genes related to alcoholism risk. In addition, different strategies such as candidate gene analyses and genome-wide association studies have been used. The strongest effects have been found for specific variants of genes that encode two enzymes involved in alcohol metabolism- alcohol dehydrogenase and aldehyde dehydrogenase. Accumulating evidence indicates that variations in numerous other genes have smaller but measurable effects.

Original languageEnglish
Pages (from-to)336-338
Number of pages3
JournalAlcohol Research and Health
Volume34
Issue number3
StatePublished - 2011

Fingerprint

Alcoholism
Genes
Aldehyde Dehydrogenase
Alcohol Dehydrogenase
Genome-Wide Association Study
Genetic Association Studies
Case-Control Studies
Alcohols
Research Personnel
Enzymes

Keywords

  • Alcohol dehydrogenase
  • Alcohol metabolism
  • Alcoholism
  • Aldehyde dehydirogenase
  • Candidate gene analyses
  • Case-control studies
  • Family studies
  • Genetic basis of alcoholism
  • Genetic factors
  • Genetics
  • Genome-wide association studies
  • Human studies

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Genes contributing to the development of alcoholism : An overview. / Edenberg, Howard.

In: Alcohol Research and Health, Vol. 34, No. 3, 2011, p. 336-338.

Research output: Contribution to journalArticle

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