Genes contributing to the development of alcoholism: An overview

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Genetic factors (i.e., variations in specific genes) account for a substantial portion of the risk for alcoholism. However, identifying those genes and the specific variations involved is challenging. Researchers have used both case-control and family studies to identify genes related to alcoholism risk. In addition, different strategies such as candidate gene analyses and genome-wide association studies have been used. The strongest effects have been found for specific variants of genes that encode two enzymes involved in alcohol metabolism- alcohol dehydrogenase and aldehyde dehydrogenase. Accumulating evidence indicates that variations in numerous other genes have smaller but measurable effects.

Original languageEnglish (US)
Pages (from-to)336-338
Number of pages3
JournalAlcohol Research and Health
Volume34
Issue number3
StatePublished - Dec 1 2011

Keywords

  • Alcohol dehydrogenase
  • Alcohol metabolism
  • Alcoholism
  • Aldehyde dehydirogenase
  • Candidate gene analyses
  • Case-control studies
  • Family studies
  • Genetic basis of alcoholism
  • Genetic factors
  • Genetics
  • Genome-wide association studies
  • Human studies

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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