Genes influencing Parkinson disease onset: Replication of PARK3 and identification of novel loci

N. Pankratz, S. K. Uniacke, C. A. Halter, A. Rudolph, C. W. Shults, P. M. Conneally, Tatiana Foroud, W. C. Nichols

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

A genome screen to identify genes influencing the age at Parkinson disease (PD) onset was completed using 276 families without parkin mutations. Significant evidence of linkage to chromosome 2p near the PARK3 locus (logarithm of odds [lod] = 4.8) was observed. Evidence of linkage was also detected to chromosomes 1q (lod = 3.0) and 8q (lod = 2.6). These data suggest that the genes influencing age at PD onset likely differ from those that contribute to PD susceptibility.

Original languageEnglish
Pages (from-to)1616-1618
Number of pages3
JournalNeurology
Volume62
Issue number9
StatePublished - May 11 2004

Fingerprint

Parkinson Disease
Chromosomes
Disease Susceptibility
Genes
Genome
Mutation
Parkinson Disease 10

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Pankratz, N., Uniacke, S. K., Halter, C. A., Rudolph, A., Shults, C. W., Conneally, P. M., ... Nichols, W. C. (2004). Genes influencing Parkinson disease onset: Replication of PARK3 and identification of novel loci. Neurology, 62(9), 1616-1618.

Genes influencing Parkinson disease onset : Replication of PARK3 and identification of novel loci. / Pankratz, N.; Uniacke, S. K.; Halter, C. A.; Rudolph, A.; Shults, C. W.; Conneally, P. M.; Foroud, Tatiana; Nichols, W. C.

In: Neurology, Vol. 62, No. 9, 11.05.2004, p. 1616-1618.

Research output: Contribution to journalArticle

Pankratz, N, Uniacke, SK, Halter, CA, Rudolph, A, Shults, CW, Conneally, PM, Foroud, T & Nichols, WC 2004, 'Genes influencing Parkinson disease onset: Replication of PARK3 and identification of novel loci', Neurology, vol. 62, no. 9, pp. 1616-1618.
Pankratz N, Uniacke SK, Halter CA, Rudolph A, Shults CW, Conneally PM et al. Genes influencing Parkinson disease onset: Replication of PARK3 and identification of novel loci. Neurology. 2004 May 11;62(9):1616-1618.
Pankratz, N. ; Uniacke, S. K. ; Halter, C. A. ; Rudolph, A. ; Shults, C. W. ; Conneally, P. M. ; Foroud, Tatiana ; Nichols, W. C. / Genes influencing Parkinson disease onset : Replication of PARK3 and identification of novel loci. In: Neurology. 2004 ; Vol. 62, No. 9. pp. 1616-1618.
@article{e8972bb8c84046b4b7470279eb4f52ec,
title = "Genes influencing Parkinson disease onset: Replication of PARK3 and identification of novel loci",
abstract = "A genome screen to identify genes influencing the age at Parkinson disease (PD) onset was completed using 276 families without parkin mutations. Significant evidence of linkage to chromosome 2p near the PARK3 locus (logarithm of odds [lod] = 4.8) was observed. Evidence of linkage was also detected to chromosomes 1q (lod = 3.0) and 8q (lod = 2.6). These data suggest that the genes influencing age at PD onset likely differ from those that contribute to PD susceptibility.",
author = "N. Pankratz and Uniacke, {S. K.} and Halter, {C. A.} and A. Rudolph and Shults, {C. W.} and Conneally, {P. M.} and Tatiana Foroud and Nichols, {W. C.}",
year = "2004",
month = "5",
day = "11",
language = "English",
volume = "62",
pages = "1616--1618",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Genes influencing Parkinson disease onset

T2 - Replication of PARK3 and identification of novel loci

AU - Pankratz, N.

AU - Uniacke, S. K.

AU - Halter, C. A.

AU - Rudolph, A.

AU - Shults, C. W.

AU - Conneally, P. M.

AU - Foroud, Tatiana

AU - Nichols, W. C.

PY - 2004/5/11

Y1 - 2004/5/11

N2 - A genome screen to identify genes influencing the age at Parkinson disease (PD) onset was completed using 276 families without parkin mutations. Significant evidence of linkage to chromosome 2p near the PARK3 locus (logarithm of odds [lod] = 4.8) was observed. Evidence of linkage was also detected to chromosomes 1q (lod = 3.0) and 8q (lod = 2.6). These data suggest that the genes influencing age at PD onset likely differ from those that contribute to PD susceptibility.

AB - A genome screen to identify genes influencing the age at Parkinson disease (PD) onset was completed using 276 families without parkin mutations. Significant evidence of linkage to chromosome 2p near the PARK3 locus (logarithm of odds [lod] = 4.8) was observed. Evidence of linkage was also detected to chromosomes 1q (lod = 3.0) and 8q (lod = 2.6). These data suggest that the genes influencing age at PD onset likely differ from those that contribute to PD susceptibility.

UR - http://www.scopus.com/inward/record.url?scp=2342611060&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2342611060&partnerID=8YFLogxK

M3 - Article

C2 - 15136695

AN - SCOPUS:2342611060

VL - 62

SP - 1616

EP - 1618

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 9

ER -